4-Methoxycarbonylnicotinoyl chloride

Base Information

Chemical Name:4-Methoxycarbonylnicotinoyl chloride
CAS No.:38173-40-9
Molecular Formula:C8H6ClNO3
Molecular Weight:199.594
Hs Code.:
DSSTox Substance ID:DTXSID301185353
Mol file:38173-40-9.mol

Synonyms:4-methoxycarbonylnicotinoyl chloride;38173-40-9;SCHEMBL3459640;RWKNQGCJEPRQSS-UHFFFAOYSA-N;DTXSID301185353;methyl 3-chlorocarbonylisonicotinate;3-Chlorocarbonyl-isonicotinic acid methyl ester;4-Pyridinecarboxylic acid, 3-(chlorocarbonyl)-, methyl ester

Suppliers and Price of 4-Methoxycarbonylnicotinoyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-Methoxycarbonylnicotinoyl chloride

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:199.0036207
Heavy Atom Count:13
Complexity:219

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C(C=NC=C1)C(=O)Cl

Technology Process of 4-Methoxycarbonylnicotinoyl chloride

There total 1 articles about 4-Methoxycarbonylnicotinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4664-08-8
cinchomeronic anhydride

: 38173-40-9
4-methoxycarbonyl-3-pyridylcarbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / 2.) conc. HCl / tetrahydrofuran; methanol; H₂O / 1.) from -70 deg C to RT, overnight, 2.) 0 deg C

2: 78 percent / SOCl₂ / benzene / Heating

With hydrogenchloride; thionyl chloride; In tetrahydrofuran; methanol; water; benzene;
DOI:10.1021/jo00350a001

Reference yield:

: 868591-19-9
[4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amine

: 38173-40-9
4-methoxycarbonyl-3-pyridylcarbonyl chloride

: 3-([4-(4-isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-carbamoyl)-isonicotinic acid methyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; for 7h;

Reference yield:

: 38173-40-9
4-methoxycarbonyl-3-pyridylcarbonyl chloride

: 139260-65-4
1-(5-Methoxy-1-phenylsulphonylindol-2-yl)-1-methylfuro<3,4-c>pyridin-3(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 18 h / Ambient temperature

2: 49.5 percent / diethyl ether / 18 h / Ambient temperature

3: 1) BuLi / 1) THF, room temp., 2 h; 2) THF, -13 deg C, then 18 h at room temp.

4: 80 percent / aq. HCl / 18 h

With hydrogenchloride; n-butyllithium; In diethyl ether; dichloromethane;
DOI:10.1039/P19910003165