1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone

Base Information

• Chemical Name: 1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone
• CAS No.: 99532-65-7
• Molecular Formula: C₂₂H₁₆N₂O₅S
• Molecular Weight: 420.445
• Mol file: 99532-65-7.mol

Synonyms:1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone

Chemical Property of 1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone

There total 3 articles about 1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cinchomeronic anhydride (4664-08-8) → 1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone (99532-65-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / 2.) conc. HCl / tetrahydrofuran; methanol; H₂O / 1.) from -70 deg C to RT, overnight, 2.) 0 deg C

2: 78 percent / SOCl₂ / benzene / Heating

3: 1.) AlCl₃ / 1.) CH₂Cl₂, 25 deg C, 10 min, 2.) CH₂Cl₂, 25 deg C

With hydrogenchloride; aluminium trichloride; thionyl chloride; In tetrahydrofuran; methanol; water; benzene;

DOI:10.1021/jo00350a001

Reference yield:

4-(methoxycarbonyl)nicotinic acid (24202-74-2) → 1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone (99532-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / SOCl₂ / benzene / Heating

2: 1.) AlCl₃ / 1.) CH₂Cl₂, 25 deg C, 10 min, 2.) CH₂Cl₂, 25 deg C

With aluminium trichloride; thionyl chloride; In benzene;

DOI:10.1021/jo00350a001

Reference yield:

1-benzenesulfonylindole (40899-71-6) + 4-methoxycarbonyl-3-pyridylcarbonyl chloride (38173-40-9) → 1-(phenylsulfonyl)indol-3-yl 4-carbomethoxy-3-pyridyl ketone (99532-65-7)

Guidance literature:

With aluminium trichloride; Yield given. Multistep reaction; 1.) CH₂Cl₂, 25 deg C, 10 min, 2.) CH₂Cl₂, 25 deg C;

DOI:10.1021/jo00350a001

upstream raw materials:

1-benzenesulfonylindole

4-methoxycarbonyl-3-pyridylcarbonyl chloride

cinchomeronic anhydride

4-(methoxycarbonyl)nicotinic acid

Downstream raw materials:

5H-pyrido[4,3-b]carbazole-5,11(6H)-dione