(-)-Hygrine

Base Information

Chemical Name:(-)-Hygrine
CAS No.:65941-22-2
Molecular Formula:C8H15NO
Molecular Weight:141.213
Hs Code.:
UNII:5CX6437M9T
DSSTox Substance ID:DTXSID20332057
Nikkaji Number:J918.167I
Wikidata:Q27105231
Metabolomics Workbench ID:52801

Synonyms:(-)-Hygrine;65941-22-2;L-(-)-Hygrine;Hygrine, (-)-;(S)-(-)-Hygrine;(S)-hygrine;5CX6437M9T;UNII-5CX6437M9T;1-[(2S)-1-methylpyrrolidin-2-yl]propan-2-one;2-Propanone, 1-((2S)-1-methyl-2-pyrrolidinyl)-;1-[(2S)-1-methylpyrrolidin-2-yl]acetone;(?)-Hygrine;N-Methyl-2-acetonylpyrrolidine, (R)-;CHEBI:92;DTXSID20332057;Q27105231

Suppliers and Price of (-)-Hygrine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (-)-Hygrine

Chemical Property:

Vapor Pressure:0.452mmHg at 25°C
Boiling Point:194°C at 760 mmHg
PKA:9.85±0.40(Predicted)
Flash Point:59.2°C
PSA：20.31000
Density:0.935g/cm³
LogP:0.99760
XLogP3:0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:141.115364102
Heavy Atom Count:10
Complexity:133

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)CC1CCCN1C
Isomeric SMILES:CC(=O)C[C@@H]1CCCN1C

Technology Process of (-)-Hygrine

There total 11 articles about (-)-Hygrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1350627-35-8
ethyl (2S)-2-(2'-oxopropyl)pyrrolidine-1-carboxylate

: 65941-22-2
(-)-hygrine

Guidance literature:: ethyl (2S)-2-(2'-oxopropyl)pyrrolidine-1-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; Reflux;

With Dess-Martin periodane; In dichloromethane; at 20 ℃;
DOI:10.1002/open.201402128

Reference yield:

: C₁₀H₁₉NO₃

: 65941-22-2
(-)-hygrine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.12.133

Reference yield:

: methyl 3-[(1R)-1-phenylethylaziridin-2-yl]propanoate

: 65941-22-2
(-)-hygrine

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetonitrile / 0.17 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / water / 1 h / Inert atmosphere; Reflux

3.1: sulfuric acid / water / 8 h / Inert atmosphere; Reflux

4.1: palladium(II) hydroxide / methanol / 6 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: trimethylaluminum / dichloromethane; hexane / 1 h / 0 - 20 °C / Inert atmosphere

5.2: Inert atmosphere

6.1: tetrahydrofuran / 4.5 h / -78 - -45 °C / Inert atmosphere

6.2: Inert atmosphere

7.1: toluene-4-sulfonic acid / methanol / 1.5 h / 40 °C / Inert atmosphere

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; trimethylaluminum; palladium(II) hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tetlet.2014.12.133