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1-Methyl-2-pyrrolidinone

Base Information Edit
  • Chemical Name:1-Methyl-2-pyrrolidinone
  • CAS No.:872-50-4
  • Deprecated CAS:26138-58-9,53774-35-9,57762-46-6,53774-35-9,57762-46-6
  • Molecular Formula:C5H9NO
  • Molecular Weight:99.1326
  • Hs Code.:2933199090
  • European Community (EC) Number:212-828-1
  • ICSC Number:0513
  • NSC Number:4594
  • UN Number:1993
  • UNII:JR9CE63FPM
  • DSSTox Substance ID:DTXSID6020856
  • Nikkaji Number:J26.033I
  • Wikipedia:N-Methyl-2-pyrrolidone
  • Wikidata:Q33103
  • NCI Thesaurus Code:C77542
  • RXCUI:1305552
  • Pharos Ligand ID:1J26YYS6USMK
  • Metabolomics Workbench ID:53310
  • ChEMBL ID:CHEMBL12543
  • Mol file:872-50-4.mol
1-Methyl-2-pyrrolidinone

Synonyms:1-methyl-2-pyrrolidinone;1-methyl-2-pyrrolidinone, 1-methyl-(14)C-labeled;1-methyl-2-pyrrolidinone, 2,3,4,5-(14)C-labeled;methyl pyrrolidone;N-methyl-2-pyrrolidinone;N-methyl-2-pyrrolidone;N-methylpyrrolidinone;N-methylpyrrolidone;pharmasolve

Suppliers and Price of 1-Methyl-2-pyrrolidinone
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • 1-Methyl-2-pyrrolidinone
  • 5g
  • $ 65.00
  • TCI Chemical
  • 1-Methyl-2-pyrrolidone >99.0%(GC)
  • 100mL
  • $ 23.00
  • TCI Chemical
  • 1-Methyl-2-pyrrolidone >99.0%(GC)
  • 25mL
  • $ 17.00
  • TCI Chemical
  • 1-Methyl-2-pyrrolidone >99.0%(GC)
  • 500mL
  • $ 36.00
  • Sigma-Aldrich
  • 1-Methyl-2-pyrrolidone for Peptide Synthesis. CAS 872-50-4, pH 8.5 - 10.0 (100 g/l, H O, 20 °C)., for Peptide Synthesis
  • 1005744000
  • $ 563.00
  • Sigma-Aldrich
  • 1-Methyl-2-pyrrolidone for Peptide Synthesis
  • 4 L
  • $ 539.27
  • Sigma-Aldrich
  • 1-Methyl-2-pyrrolidinone anhydrous, 99.5%
  • 18l
  • $ 1390.00
  • Sigma-Aldrich
  • 1-Methyl-2-pyrrolidinone for HPLC, ≥99%
  • 4x4l
  • $ 1380.00
  • Sigma-Aldrich
  • 1-Methyl-2-pyrrolidone EMPLURA
  • 8060729025
  • $ 1380.00
  • Sigma-Aldrich
  • 1-Methyl-2-pyrrolidinone anhydrous, 99.5%
  • 18l-p1
  • $ 1370.00
Total 382 raw suppliers
Chemical Property of 1-Methyl-2-pyrrolidinone Edit
Chemical Property:
  • Appearance/Colour:colourless or light yellow liquid with an amine odour 
  • Vapor Pressure:0.29 mm Hg ( 20 °C) 
  • Melting Point:-24 °C 
  • Refractive Index:n20/D 1.479  
  • Boiling Point:201.999 °C at 760 mmHg 
  • PKA:-0.41±0.20(Predicted) 
  • Flash Point:86.111 °C 
  • PSA:20.31000 
  • Density:1.033 
  • LogP:0.17650 
  • Storage Temp.:2-8°C 
  • Sensitive.:Hygroscopic 
  • Solubility.:ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v) 
  • Water Solubility.:>=10 g/100 mL at 20 ºC 
  • XLogP3:-0.5
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:1
  • Rotatable Bond Count:0
  • Exact Mass:99.068413911
  • Heavy Atom Count:7
  • Complexity:90.1
  • Transport DOT Label:Combustible Liquid
Purity/Quality:

99.85% *data from raw suppliers

1-Methyl-2-pyrrolidinone *data from reagent suppliers

Safty Information:
  • Pictogram(s): ToxicT,IrritantXi 
  • Hazard Codes:T,Xi 
  • Statements: 45-65-36/38-36/37/38-61-10-46 
  • Safety Statements: 41-45-53-62-26 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Chemical Classes:Solvents -> Other Solvents
  • Canonical SMILES:CN1CCCC1=O
  • Recent ClinicalTrials:NMP in Relapsed / Refractory Myeloma
  • Inhalation Risk:A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.
  • Effects of Short Term Exposure:The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. Exposure to very high concentrations could cause lowering of consciousness.
  • Effects of Long Term Exposure:Repeated or prolonged contact with skin may cause dermatitis. Animal tests show that this substance possibly causes toxic effects upon human reproduction.
  • Uses N-Methyl-2-pyrrolidone (NMP) is a polar aprotic solvent that has the advantages of low toxicity, high boiling point, outstanding solvency, strong selectivity and good stability. It is widely used in purification of aromatic hydrocarbon extraction, acetylene, olefins, and diolefins.It is used in industrial cleaning, and it serves as a solvent for production of pesticides, engineering plastics, coatings, synthetic fibers, and integrated circuits.It can also be used as an industrial cleanser, dispersant, dye, lubricant and antifreeze.N-Methyl-2-pyrrolidone is an excellent solvent, widely used in aromatics extraction, lubricating oil refining, acetylene enrichment, butadiene separation and synthesis gas desulfurization.It is used in gas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extraction, and as a solvent for insoluble engineering plastics polymerization.It can be used in herbicide, to clean insulation materials, semiconductor industry precision instruments and circuit boards, to recycle PVC exhaust, as a detergent, dye supplement and dispersing agent.It is used in mediums for polymerization reactions such as engineering plastics and aramid fiber.N-Methyl-2-pyrrolidone is used as a polyvinylidene fluoride solvent and electrode auxiliary material for lithium ion batteries.high purity grade for ICP-MS detection.For peptide synthesis. N-Methyl-2-pyrrolidone?is a polar solvent that is used in organic chemistry and polymer chemistry. Large scale applications include the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks.N-Methyl-2-pyrrolidone?is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts. Solvent for high-temperature resins; petrochemical processing, in the microelectronics fabrication industry, dyes and pigments, industrial and domestic cleaning compounds; agricultural and pharmaceutical formulations N-Methyl-2-pyrrolidone, is useful for spectrophotometry, chromatography and ICP-MS detection.
  • Description N-Methyl-2-pyrrolidone is an aprotic solvent with a wide range of applications: petrochemical processing, surface coating, dyes and pigments, industrial and domestic cleaning compounds, and agricultural and pharmaceutical formulations. It is mainly an irritant, but has also caused several cases of contact dermatitis in a small electrotechnical company.
Technology Process of 1-Methyl-2-pyrrolidinone

There total 101 articles about 1-Methyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With sodium isopropylate; In isopropyl alcohol; at 60 ℃; for 3h;
Guidance literature:
With water; ZSM-5; at 280 ℃;
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