3-(2-Hydroxy-5-methoxy-phenyl)-acrylic acid

Base Information

• Chemical Name: 3-(2-Hydroxy-5-methoxy-phenyl)-acrylic acid
• CAS No.: 38489-78-0
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.187
• Hs Code.: 2918990090
• Mol file: 38489-78-0.mol

Synonyms:38489-78-0;3-(2-Hydroxy-5-methoxy-phenyl)-acrylic acid;3-(2-hydroxy-5-methoxyphenyl)acrylic acid;(E)-3-(2-hydroxy-5-methoxyphenyl)acrylic acid;3-(2-hydroxy-5-methoxyphenyl)prop-2-enoic acid;starbld0000235;oxy-5-methoxycinnamic acid;SCHEMBL10321325;AKOS006277056;CS-0451963;EN300-1855463;(E)-3-(2-hydroxy-5-methoxyphenyl)prop-2-enoic acid

Chemical Property of 3-(2-Hydroxy-5-methoxy-phenyl)-acrylic acid

Chemical Property:

• Vapor Pressure: 3.3E-07mmHg at 25°C
• Boiling Point: 402.7oC at 760 mmHg
• Flash Point: 164.2oC
• PSA: 66.76000
• Density: 1.316g/cm3
• LogP: 1.49860
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 194.05790880
• Heavy Atom Count: 14
• Complexity: 224

Purity/Quality:

97% ^*data from raw suppliers

3-(2-hydroxy-5-methoxy-phenyl)-acrylicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)O)C=CC(=O)O
• Isomeric SMILES: COC1=CC(=C(C=C1)O)/C=C/C(=O)O

Technology Process of 3-(2-Hydroxy-5-methoxy-phenyl)-acrylic acid

There total 5 articles about 3-(2-Hydroxy-5-methoxy-phenyl)-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.2%

3-methyl-4-nitro-5-<2-(2-hydroxy-5-methoxyphenyl)ethenyl>isoxazole (85364-68-7) → (E)-2-hydroxy-5-methoxycinnamic acid (38489-78-0)

Guidance literature:

With sodium hydroxide; for 2h; Heating;

Reference yield:

2-hydroxy-5-methoxybenzaldehyde (672-13-9) + malonic acid (141-82-2) → (E)-2-hydroxy-5-methoxycinnamic acid (38489-78-0)

Guidance literature:

With piperidine; In pyridine; at 120 ℃; for 1.5h;

DOI:10.1039/c4md00022f

Reference yield:

6-methoxycoumarin (17372-53-1) → (E)-2-hydroxy-5-methoxycinnamic acid (38489-78-0)

Guidance literature:

With sodium sulfite; anschliessendes Erhitzen mit wss. KOH;

DOI:10.1002/ardp.19572901003

upstream raw materials:

6-methoxycoumarin

2-hydroxy-5-methoxybenzaldehyde

(carbethoxymethyl)triphenylphosphonium bromide

3-methyl-4-nitro-5-<2-(2-hydroxy-5-methoxyphenyl)ethenyl>isoxazole

Downstream raw materials:

(E)-3-(5-methoxy-2-((3,5,6-trimethylpyrazine-2-carbonyl)oxy)phenyl)acrylic acid

(E)-2-(3-ethoxy-3-oxoprop-1-en-1-yl)-4-methoxyphenyl 3,5,6-trimethylpyrazine-2-carboxylate