5-[(E)-(3-chlorophenyl)diazenyl]-2-hydroxybenzaldehyde

Base Information

• Chemical Name: 5-[(E)-(3-chlorophenyl)diazenyl]-2-hydroxybenzaldehyde
• CAS No.: 38501-85-8
• Molecular Formula: C13H9ClN2O2
• Molecular Weight: 260.68
• DSSTox Substance ID: DTXSID70425509
• Mol file: 38501-85-8.mol

Synonyms:5-[(E)-(3-chlorophenyl)diazenyl]-2-hydroxybenzaldehyde;952665-71-3;38501-85-8;Benzaldehyde, 5-[(3-chlorophenyl)azo]-2-hydroxy-;DTXSID70425509;BBL023792;STL289216;AKOS022061473;VS-07513;CS-0335905;(E)-5-((3-chlorophenyl)diazenyl)-2-hydroxybenzaldehyde;5-[(1E)-2-(3-chlorophenyl)diazen-1-yl]-2-hydroxybenzaldehyde

Chemical Property of 5-[(E)-(3-chlorophenyl)diazenyl]-2-hydroxybenzaldehyde

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 260.0352552
• Heavy Atom Count: 18
• Complexity: 311

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Cl)N=NC2=CC(=C(C=C2)O)C=O

Technology Process of 5-[(E)-(3-chlorophenyl)diazenyl]-2-hydroxybenzaldehyde

There total 2 articles about 5-[(E)-(3-chlorophenyl)diazenyl]-2-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-benzyl alcohol (89-95-2) + 3-chloro-aniline (108-42-9) → 5-(3-chlorophenylazo)salicylaldehyde (38501-85-8)

Guidance literature:

3-chloro-aniline; With hydrogenchloride; sodium nitrite; at 0 - 5 ℃;

2-methyl-benzyl alcohol; With sodium hydroxide; at 0 - 5 ℃; for 4h;

Reference yield:

salicylaldehyde (90-02-8) + 3-chloro-aniline (108-42-9) → 5-(3-chlorophenylazo)salicylaldehyde (38501-85-8)

Guidance literature:

3-chloro-aniline; With hydrogenchloride; sodium nitrite; at 0 - 5 ℃; pH=8 - 10;

salicylaldehyde; With potassium carbonate;

DOI:10.1111/cbdd.13335

Reference yield: 95.0%

1H-indene-1,3(2H)-dione (606-23-5) + 5-(3-chlorophenylazo)salicylaldehyde (38501-85-8) + 3-methyl-5-aminopyrazole (31230-17-8) → 4-(2-hydroxy-5-((3-chlorophenyl)diazenyl)phenyl)-3-methyl-4,10-dihydroindeno[1,2-b]pyrazolo[4,3-e]pyridin-5(1H)-one (1374117-65-3)

Guidance literature:

With iron(II,III) oxide; In water; for 0.0833333h; Reflux;

DOI:10.1002/cjoc.201100181

upstream raw materials:

2-methyl-benzyl alcohol

3-chloro-aniline

salicylaldehyde

Downstream raw materials:

2-[1-[5-(3-Chloro-phenylazo)-2-hydroxy-phenyl]-meth-(E)-ylidene-hydrazinocarbonyl]-N-phenyl-acetamide

N-(4-Chloro-phenyl)-2-[1-[5-(3-chloro-phenylazo)-2-hydroxy-phenyl]-meth-(E)-ylidene-hydrazinocarbonyl]-acetamide

N-(2-Chloro-phenyl)-2-[1-[5-(3-chloro-phenylazo)-2-hydroxy-phenyl]-meth-(E)-ylidene-hydrazinocarbonyl]-acetamide

N-(3-Chloro-phenyl)-2-[1-[5-(3-chloro-phenylazo)-2-hydroxy-phenyl]-meth-(E)-ylidene-hydrazinocarbonyl]-acetamide