2H-Isoindole-2-acetic acid, a-(1,1-dimethylethyl)-1,3-dihydro-1,3-dioxo-

Base Information

Chemical Name:2H-Isoindole-2-acetic acid, a-(1,1-dimethylethyl)-1,3-dihydro-1,3-dioxo-
CAS No.:3850-33-7
Molecular Formula:C14H15NO4
Molecular Weight:261.277
Hs Code.:

Synonyms:3,3-dimethyl-2-phthalimido-butyric acid;2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyric acid;N-Phthaloyl-tert-leucin;(+/-)-N-phthaloyl-tert-leucine;

Suppliers and Price of 2H-Isoindole-2-acetic acid, a-(1,1-dimethylethyl)-1,3-dihydro-1,3-dioxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2H-Isoindole-2-acetic acid, a-(1,1-dimethylethyl)-1,3-dihydro-1,3-dioxo-

Chemical Property:

Melting Point:190 - 190.5 °C
Boiling Point:419.7±28.0 °C(Predicted)
PSA：74.68000
Density:1.313±0.06 g/cm3(Predicted)
LogP:1.71980

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2H-Isoindole-2-acetic acid, a-(1,1-dimethylethyl)-1,3-dihydro-1,3-dioxo-

There total 1 articles about 2H-Isoindole-2-acetic acid, a-(1,1-dimethylethyl)-1,3-dihydro-1,3-dioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 85-44-9
phthalic anhydride

: 33105-81-6
2-amino-3,3-dimethylbutanoic acid

: 3850-33-7
2-(1,3-dioxoisoindolin-2-yl)-3,3-dimethylbutanoic acid

Guidance literature:: at 170 ℃; for 2h;
DOI:10.1021/jacs.5b02244

Reference yield: 23.0%

: 3850-33-7
2-(1,3-dioxoisoindolin-2-yl)-3,3-dimethylbutanoic acid

: 624-31-7
4-tolyl iodide

: C₂₁H₂₁NO₄

Guidance literature:: With dipotassium hydrogenphosphate; C₂₇H₃₄N₂O; palladium diacetate; silver carbonate; at 100 ℃; for 24h; Sealed tube;
DOI:10.1002/anie.201610580

Reference yield:

: 3850-33-7
2-(1,3-dioxoisoindolin-2-yl)-3,3-dimethylbutanoic acid

: N-[3,3-dimethyl-1-oxo-1-(quinolin-8-ylamino)butan-2-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / Inert atmosphere

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

3: 1,10-Phenanthroline; potassium carbonate; palladium diacetate / isopropyl alcohol / 80 °C / Schlenk technique; Sealed tube

With 1,10-Phenanthroline; oxalyl dichloride; palladium diacetate; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/acs.joc.1c02162