(2-Amino-1H-benzimidazol-1-yl)(3,5-dichloro-2-methoxyphenyl)methanone

Base Information

Chemical Name:(2-Amino-1H-benzimidazol-1-yl)(3,5-dichloro-2-methoxyphenyl)methanone
CAS No.:385416-70-6
Molecular Formula:C15H11Cl2N3O2
Molecular Weight:336.177
Hs Code.:
DSSTox Substance ID:DTXSID70580147
Wikidata:Q82470907
Mol file:385416-70-6.mol

Synonyms:385416-70-6;DTXSID70580147;(2-Amino-1H-benzimidazol-1-yl)(3,5-dichloro-2-methoxyphenyl)methanone

Suppliers and Price of (2-Amino-1H-benzimidazol-1-yl)(3,5-dichloro-2-methoxyphenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (2-Amino-1H-benzimidazol-1-yl)(3,5-dichloro-2-methoxyphenyl)methanone

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:335.0228320
Heavy Atom Count:22
Complexity:426

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=C1Cl)Cl)C(=O)N2C3=CC=CC=C3N=C2N

Technology Process of (2-Amino-1H-benzimidazol-1-yl)(3,5-dichloro-2-methoxyphenyl)methanone

There total 3 articles about (2-Amino-1H-benzimidazol-1-yl)(3,5-dichloro-2-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 934-32-7
1H-benzimidazol-2-amine

: 5213-08-1
3,5-dichloro-2-methoxybenzoyl chloride

: 385416-70-6
(2-amino-benzoimidazol-1-yl)-(3,5-dichloro-2-methoxy-phenyl)-methanone

Guidance literature:: DOI:10.1134/S1070363206100264

Reference yield:

: 22775-37-7
3,5-dichloro-2-methoxybenzoic acid

: 385416-70-6
(2-amino-benzoimidazol-1-yl)-(3,5-dichloro-2-methoxy-phenyl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dimethylformamide / CHCl₃ / Heating

2: 76.4 percent / triethylamine / acetone / 55 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In chloroform; acetone;
DOI:10.1023/B:RUGC.0000039088.87053.eb

Reference yield:

: 69-72-7,25496-36-0,8052-31-1
salicylic acid

: 385416-70-6
(2-amino-benzoimidazol-1-yl)-(3,5-dichloro-2-methoxy-phenyl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / chlorine / acetic acid / 35 °C

2: sodium hydroxide / H₂O / 4 h / 95 - 100 °C

3: thionyl chloride / dimethylformamide / CHCl₃ / Heating

4: 76.4 percent / triethylamine / acetone / 55 °C

With sodium hydroxide; thionyl chloride; chlorine; triethylamine; N,N-dimethyl-formamide; In chloroform; water; acetic acid; acetone;
DOI:10.1023/B:RUGC.0000039088.87053.eb