Refernces
10.1080/00397910801982001
The study presents a novel synthetic method for the production of 5-(N-phenethylamino)salicylic acid derivatives, which are compounds with potential neuroprotective activity against N-methyl-D-aspartic acid (NMDA) neurotoxicity and strong antioxidant properties. The researchers utilized sodium borohydride (NaBH4) and acetic acid as the key reagents in a dioxane system to selectively reduce the amide group over the ester group in acyl-protected salicylic acid derivatives. This selective reduction was followed by the hydrolysis of the ester group to yield the desired salicylic acid products. The chemicals served the purpose of facilitating a rapid and selective synthesis route, which is advantageous for producing various 5-(N-phenethylamino)salicylic acid derivatives and can be applied to scaled-up production.
10.1039/DT9950000771
This research presents the synthesis, crystal structure, and catalytic activity of two manganese(II) salicylate complexes: [Mn2(Hsal)2(H2O)2] (complex 1) and polymeric [{Mn2(sal)2(Hsal)(H2O)(H2O)(py)4}n] (complex 2), where Hsal represents salicylic acid and py is pyridine. The study aims to contribute to the understanding of carboxylate-bridged multinuclear manganese complexes, which are of interest due to their relevance to Mn-containing enzymes and their potential as models for metal interactions with humic materials in the environment. The complexes were found to be air-stable and showed enhanced catalytic activity towards the disproportionation of H2O2 in the presence of added pyridine, suggesting a role for nitrogen-containing heterocyclic bases in manganocatalases. The chemicals used in the synthesis and characterization of these complexes include salicylic acid, manganese(II) chloride tetrahydrate, pyridine, and various solvents such as water, ethanol, dimethylformamide, and tetrahydrofuran.
10.1016/S0020-1693(01)00605-3
The research aimed to investigate the impact of hydrogen bonding on coordination, particularly semi-coordination, in transition metal complexes, using trans-di(salicylato)bis(1,3-diaminopropane-N,N’)copper(II) as a model compound. The study employed single-crystal X-ray diffraction methods at 193(2) K to determine the crystal and molecular structure of the complex. The central copper(II) ion was found to occupy a center of symmetry within a monomeric complex unit, with the coordination polyhedron described as an axially elongated distorted octahedron, indicative of semi-coordination. The research concluded that semi-coordination is characterized by electrostatic attraction between the central copper(II) cation and repulsion between an electron lone pair of a ligand atom and the electron lone pair at the copper(II) 3dz2 atomic orbital. The chemicals used in the synthesis of the complex included salicylic acid, CuCO3, and 1,3-diaminopropane, with the final product being characterized by various analytical methods.
Xn
Xn:Harmful;
