Benzoic acid, 4-(3-chloro-1-phenylpropoxy)-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 4-(3-chloro-1-phenylpropoxy)-, methyl ester
• CAS No.: 385436-89-5
• Molecular Formula: C₁₇H₁₇ClO₃
• Molecular Weight: 304.773
• Mol file: 385436-89-5.mol

Synonyms:4-(3-Chloro-1-phenyl-propoxy)-benzoic Acid Methyl Ester;Benzoic acid,4-(3-chloro-1-phenylpropoxy)-,methyl ester;

Chemical Property of Benzoic acid, 4-(3-chloro-1-phenylpropoxy)-, methyl ester

Chemical Property:

• Boiling Point: 439.1±30.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.185±0.06 g/cm3(Predicted)
• LogP: 4.22220

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-(3-chloro-1-phenylpropoxy)-, methyl ester

There total 3 articles about Benzoic acid, 4-(3-chloro-1-phenylpropoxy)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

→ 4-(3-Chloro-1-phenyl-propoxy)-benzoic Acid Methyl Ester (385436-89-5)

Guidance literature:

Reference yield:

3-chloropropiophenone (936-59-4) → 4-(3-Chloro-1-phenyl-propoxy)-benzoic Acid Methyl Ester (385436-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol

2: RO₂C-N=N-CO₂R; Ph₃P / tetrahydrofuran

With sodium tetrahydroborate; RO₂C-N=N-CO₂R; triphenylphosphine; In tetrahydrofuran; methanol;

DOI:10.1016/S0960-894X(03)00126-4

Reference yield:

3-chloro-1-phenyl-propan-1-ol (18776-12-0,125712-82-5) + methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-(3-Chloro-1-phenyl-propoxy)-benzoic Acid Methyl Ester (385436-89-5)

Guidance literature:

With RO₂C-N=N-CO₂R; triphenylphosphine; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00126-4

upstream raw materials:

3-chloro-1-phenyl-propan-1-ol

methyl 4-hydroxylbenzoate

3-chloropropiophenone

Downstream raw materials:

(Methyl-{3-[4-(4-methyl-benzoyl)-phenoxy]-3-phenyl-propyl}-amino)-acetic Acid Ethyl Ester

[4-(3-Chloro-1-phenyl-propoxy)-phenyl]-p-tolyl-methanone

4-(3-chloro-1-phenyl-propoxy)-benzoyl chloride

4-(3-chloro-1-phenyl-propoxy)-benzoic acid