4-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-a-(4-fluorophenyl)-1,2,3,6-tetrahydro-

Base Information

• Chemical Name: 4-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-a-(4-fluorophenyl)-1,2,3,6-tetrahydro-
• CAS No.: 385844-15-5
• Molecular Formula: C18H22FNO4
• Molecular Weight: 335.375
• Mol file: 385844-15-5.mol

Synonyms:

Chemical Property of 4-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-a-(4-fluorophenyl)-1,2,3,6-tetrahydro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-a-(4-fluorophenyl)-1,2,3,6-tetrahydro-

There total 6 articles about 4-Pyridineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-a-(4-fluorophenyl)-1,2,3,6-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-[1-(tert-butoxycarbonyl)-4-hydroxypiperidin-4-yl](4-fluorophenyl)acetic acid (385844-14-4) + di-tert-butyl dicarbonate (24424-99-5) → [1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl](4-fluorophenyl)acetic acid (385844-15-5)

Guidance literature:

(+/-)-[1-(tert-butoxycarbonyl)-4-hydroxypiperidin-4-yl](4-fluorophenyl)acetic acid; With sulfuric acid; In chloroform; at 0 ℃; for 3h; Heating / reflux;

di-tert-butyl dicarbonate; With sodium hydroxide; In 1,4-dioxane; chloroform; water; at 0 - 20 ℃; for 0.5h;

Reference yield:

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + (+/-)-[1-(tert-butoxycarbonyl)-4-hydroxypiperidin-4-yl](4-fluorophenyl)acetic acid (385844-14-4) + di-tert-butyl dicarbonate (24424-99-5) → [1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl](4-fluorophenyl)acetic acid (385844-15-5)

Guidance literature:

With sodium hydroxide; sulfuric acid; In chloroform;

Reference yield:

(4-fluoro-phenyl)-(1,2,3,6-tetrahydro-pyridin-4-yl)-acetic acid + di-tert-butyl dicarbonate (24424-99-5) → [1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl](4-fluorophenyl)acetic acid (385844-15-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; chloroform; water; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmc.2007.01.019

upstream raw materials:

di-tert-butyl dicarbonate

(+/-)-[1-(tert-butoxycarbonyl)-4-hydroxypiperidin-4-yl](4-fluorophenyl)acetic acid

N-tert-butyloxycarbonylpiperidin-4-one

p-Fluorophenylacetic acid

Downstream raw materials:

1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine

tert-butyl 4-(1-(4-fluorophenyl)-2-{4-[4-(2-methoxy-1-naphthyl)butyl]piperazin-1-yl}-2-oxoethyl)piperidine-1-carboxylate

4-{1-(4-fluoro-phenyl)-2-[4-(4-naphthalen-1-yl-butyl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butyl ester

3-(3'-fluoro-biphenyl-2-yl)-1-{4-[(4-fluoro-phenyl)-(1-isopropyl-piperidin-4-yl)-acetyl]-piperazin-1-yl}-propan-1-one

Refernces

• 1、 -. "PIPERAZINE DERIVATIVE". Page 27. . Retrieved 2010/02/08.