1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine

Base Information

Chemical Name:1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine
CAS No.:385844-24-6
Molecular Formula:C₃₆H₄₄FN₃O₃
Molecular Weight:585.762
Hs Code.:

Synonyms:1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine

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Chemical Property of 1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine

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Technology Process of 1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine

There total 6 articles about 1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 385844-15-5
[1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl](4-fluorophenyl)acetic acid

: 1-(4-naphthalen-1-yl-butyl)piperazine dihydrochloride

: 1-ethyl-3-(3-3-dimethylaminopropyl)carbodiimide hydrochloride

: 80029-43-2,123333-53-9
1-hydroxybenzotriazol-hydrate

: 385844-24-6
1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine

Guidance literature:: With triethylamine; In N-methyl-acetamide;

Reference yield:

: 385844-15-5
[1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl](4-fluorophenyl)acetic acid

: 1-(4-naphthalen-1-yl-butyl)piperazine dihydrochloride

: 385844-24-6
1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2007.01.019

Reference yield:

: (4-fluoro-phenyl)-(1,2,3,6-tetrahydro-pyridin-4-yl)-acetic acid

: 385844-24-6
1-t-butoxycarbonyl-4-{1-(4-fluorophenyl)-2-[4-(4-naphthalen-1-yl-butyl)piperazin-1-yl]-2-oxoethyl}-3,6-dihydro-2H-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 18.0 g / NaOH / CHCl₃; H₂O; dioxane / 0.5 h / 20 °C

2: 1-hydroxybenzotriazole hydrate; triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 15 h / 20 °C

With sodium hydroxide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.01.019