H-PHE-GLY-NH2 HCL

Base Information

• Chemical Name: H-PHE-GLY-NH2 HCL
• CAS No.: 38678-61-4
• Molecular Formula: C11H15N3O2
• Molecular Weight: 221.25600
• Mol file: 38678-61-4.mol

Synonyms:D-Leucine amide;N-L-Phenylalanyl-glycin-amid;(R)-2-Amino-4-methylpentanamide;N-L-phenylalanyl-glycine amide;H-Phe-Gly-NH2;H-L-Phe-Gly-NH2;

Chemical Property of H-PHE-GLY-NH2 HCL

Chemical Property:

• PSA: 102.69000
• LogP: 1.84820
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Phe-Gly-NH2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-PHE-GLY-NH2 HCL

There total 7 articles about H-PHE-GLY-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + H-Gly-NH2 (598-41-4) → H-L-Phe-Gly-NH2 (38678-61-4)

Guidance literature:

L-phenylalanine; With phosphoric acid; In water; acetonitrile;

With methyloxirane; In dimethyl sulfoxide; at 40 ℃;

H-Gly-NH₂; Further stages;

DOI:10.1080/10426507.2010.501319

Reference yield: 88.0%

N-[1-(carbamoylmethyl-carbamoyl)-2-phenyl-ethyl]-2-(2-nitro-phenyl)-isobutyramide → 3,3-dimethyloxindole (19155-24-9) + 1,3-dihydro-3,3-dimethyl-1-hydroxy-H-indol-2-one (32353-29-0) + H-L-Phe-Gly-NH2 (38678-61-4)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; for 0.5h;

DOI:10.1016/S0040-4039(02)00891-2

Reference yield:

Fmoc-Phe-Gly-NH2 (1349173-17-6) → H-L-Phe-Gly-NH2 (38678-61-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/ja207133t

upstream raw materials:

Z-L-phenylalanylglycinamide

Boc-Phe-Gly-NH₂

Boc-Phe-ONSu

L-phenylalanine

Downstream raw materials:

C₁₅H₂₀N₄O₃

C₃₄H₃₄N₄O₃

C₂₄H₂₇N₅O₄

Refernces

• 1、 Dyer, Frank Brock,Park, Chung-Min,Joseph, Ryan,Garner, Philip. "Aziridine-mediated ligation and site-specific modification of unprotected peptides". supporting information; experimental part. p. 20033 - 20035. Retrieved 2012/01/31.
• 2、 Marastoni,Salvadori,Balboni,Scaranari,Borea,Tomatis. "Synthesis and opioid activity of tyrosine sulfate containing dermorphin and deltorphin peptides". . p. 116 - 119. Retrieved 2007/10/02.