Z-PHE-GLY-NH2

Base Information

• Chemical Name: Z-PHE-GLY-NH2
• CAS No.: 17187-05-2
• Molecular Formula: C19H21 N3 O4
• Molecular Weight: 355.393
• Hs Code.: 2924299090
• Mol file: 17187-05-2.mol

Synonyms:Carbamicacid, [a-[(carbamoylmethyl)carbamoyl]phenethyl]-,benzyl ester (6CI); Carbamic acid, [a-[(carbamoylmethyl)carbamoyl]phenethyl]-, benzylester, L- (8CI); N-(Benzyloxycarbonyl)phenylalanylglycine amide;N-Benzyloxycarbonyl-L-phenylalanylglycinamide;N-Carbobenzoxy-phenylalanyl-glycinamide

Chemical Property of Z-PHE-GLY-NH2

Chemical Property:

• PSA: 110.52000
• LogP: 2.60770
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-PHE-GLY-NH2

There total 10 articles about Z-PHE-GLY-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

glycinamide hydrochloride (1668-10-6) + N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester (60379-01-3) → Z-L-phenylalanylglycinamide (17187-05-2)

Guidance literature:

With S₁₆₆C-SBnCOOH; triethylamine; calcium chloride; In water; N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1016/S0957-4166(99)00255-4

Reference yield: 95.0%

Z-L-Phe p-chlorophenyl ester (3272-95-5) + H-Gly-NH2 (598-41-4) → Z-L-phenylalanylglycinamide (17187-05-2) + 4-chloro-phenol (106-48-9,82344-39-6)

Guidance literature:

With thiolsubtilisin; In water; N,N-dimethyl-formamide; Ambient temperature; pH 8.0 phosphate buffer containing PhB(OH)2 traces;

DOI:10.1021/ja00246a064

Reference yield: 90.0%

N-Cbz-L-Phe (1161-13-3) + glycinamide hydrochloride (1668-10-6) → Z-L-phenylalanylglycinamide (17187-05-2)

Guidance literature:

N-Cbz-L-Phe; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃;

glycinamide hydrochloride; With triethylamine; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1021/ja003770j

upstream raw materials:

N-benzyloxycarbonyl-L-phenylalanyl chloride

H-Gly-NH₂

N-carbobenzoxy-L-phenylalanine methyl ester

Z-L-Phe p-chlorophenyl ester

Downstream raw materials:

H-L-Phe-Gly-NH₂

N-benzyloxycarbonyl-L-phenylalanylglycine methyl ester