N-(3-(piperidin-4-yl)phenyl)acetamide hydrochloride

Base Information

Chemical Name:N-(3-(piperidin-4-yl)phenyl)acetamide hydrochloride
CAS No.:387827-25-0
Molecular Formula:C13H18N2O
Molecular Weight:218.299
Hs Code.:
Mol file:387827-25-0.mol

Synonyms:N1-[3-(4-piperidyl)phenyl]acetamide;N-(3-piperidin-4-ylphenyl)acetamide;N-[3-(piperidin-4-yl)phenyl]acetamide;N-[3-(4-piperidinyl)phenyl]acetamide;N-(3-(piperidin-4-yl)phenyl)acetamide;

Suppliers and Price of N-(3-(piperidin-4-yl)phenyl)acetamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N-(3-(piperidin-4-yl)phenyl)acetamide hydrochloride

Chemical Property:

PSA：41.13000
LogP:2.51380

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(3-(piperidin-4-yl)phenyl)acetamide hydrochloride

There total 6 articles about N-(3-(piperidin-4-yl)phenyl)acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 387827-24-9
tert-butyl 4-[3-(acetylamino)-phenyl]-1-piperidinecarboxylate

: 387827-25-0
N-[3-(piperidin-4-yl)phenyl]-acetamide

Guidance literature:: tert-butyl 4-[3-(acetylamino)-phenyl]-1-piperidinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium hydroxide; water; In ethyl acetate; pH=12;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 387827-25-0
N-[3-(piperidin-4-yl)phenyl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hexamethyldisilazane / -78 °C

2: -78 °C

3: potassium carbonate; palladium dichloride; triphenylphosphine

4: pyridine

5: hydrogen; palladium on activated charcoal

6: trifluoroacetic acid

With pyridine; palladium on activated charcoal; hydrogen; potassium carbonate; triphenylphosphine; trifluoroacetic acid; palladium dichloride; lithium hexamethyldisilazane; 3: |Suzuki Coupling;
DOI:10.3390/molecules181012119

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 387827-25-0
N-[3-(piperidin-4-yl)phenyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; palladium dichloride; triphenylphosphine

2: pyridine

3: hydrogen; palladium on activated charcoal

4: trifluoroacetic acid

With pyridine; palladium on activated charcoal; hydrogen; potassium carbonate; triphenylphosphine; trifluoroacetic acid; palladium dichloride; 1: |Suzuki Coupling;
DOI:10.3390/molecules181012119