1-Piperidinecarboxylic acid, 4-[3-(acetylamino)phenyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[3-(acetylamino)phenyl]-, 1,1-dimethylethyl ester
CAS No.:387827-24-9
Molecular Formula:C18H26N2O3
Molecular Weight:318.416
Hs Code.:
Mol file:387827-24-9.mol

Synonyms:t-butyl 4-(3-(acetylamino)phenyl)-piperidine-1-carboxylate;TERT-BUTYL 4-[3-(ACETYLAMINO)PHENYL]-1-PIPERIDINECARBOXYLATE;Tert-butyl 4-[3-(acetylamino) phenyl]-1-piperidinecarboxylate;tert-butyl 4[3-(acetylamino)phenyl]piperidine-1-carboxylate;4-(3-acetylaminophenyl)-piperidine-1-carboxylic acid tert-butyl ester;

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-[3-(acetylamino)phenyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 4-[3-(acetylamino)phenyl]-, 1,1-dimethylethyl ester

Chemical Property:

Melting Point:230 - 235 °C
PSA：58.64000
LogP:3.77040

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 1-Piperidinecarboxylic acid, 4-[3-(acetylamino)phenyl]-, 1,1-dimethylethyl ester

There total 6 articles about 1-Piperidinecarboxylic acid, 4-[3-(acetylamino)phenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 387827-19-2
tert-butyl 4-[3-(amino)phenyl]-1-piperidinecarboxylate

: 108-24-7
acetic anhydride

: 387827-24-9
tert-butyl 4-[3-(acetylamino)-phenyl]-1-piperidinecarboxylate

Guidance literature:: tert-butyl 4-[3-(amino)phenyl]-1-piperidinecarboxylate; acetic anhydride; In dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 3h;

Reference yield: 94.0%

: 387827-20-5
tert-butyl 4-[3-(acetylamino)-phenyl]-1,2,3,6-tetrahydro-1-pyridinecarboxylate

: 387827-24-9
tert-butyl 4-[3-(acetylamino)-phenyl]-1-piperidinecarboxylate

Guidance literature:: With 10% Pd/C; hydrogen; In ethanol; at 20 ℃; for 24h;
DOI:10.1021/jo801463j

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 387827-24-9
tert-butyl 4-[3-(acetylamino)-phenyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; palladium dichloride; triphenylphosphine

2: pyridine

3: hydrogen; palladium on activated charcoal

With pyridine; palladium on activated charcoal; hydrogen; potassium carbonate; triphenylphosphine; palladium dichloride; 1: |Suzuki Coupling;
DOI:10.3390/molecules181012119