Bamirastine

Base Information

Chemical Name:Bamirastine
CAS No.:215529-47-8
Molecular Formula:C31H37N5O3
Molecular Weight:527.666
Hs Code.:
UNII:SIG10953FN
DSSTox Substance ID:DTXSID60175889
Nikkaji Number:J1.474.730C
Wikidata:Q27289220
NCI Thesaurus Code:C79560
ChEMBL ID:CHEMBL2107732
Mol file:215529-47-8.mol

Synonyms:2-(6-((3-(4-(diphenylmethoxy)piperidino)propyl)amino)imidazo(1,2-b)pyridazin-2-yl)-2-methylpropionic acid;TAK 427;TAK-427;TAK427

Suppliers and Price of Bamirastine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Bamirastine

Chemical Property:

Melting Point:109-112 °C
PSA：95.22000
Density:1.23±0.1 g/cm3(Predicted)
LogP:4.52390
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:11
Exact Mass:527.28964006
Heavy Atom Count:39
Complexity:743

Purity/Quality:: 99%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C1=CN2C(=N1)C=CC(=N2)NCCCN3CCC(CC3)OC(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O

Technology Process of Bamirastine

There total 5 articles about Bamirastine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 215529-43-4
ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

: 215529-47-8
2-[6-[[3-[4-(diphenylmethoxy)piperidino]propyl]amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

Guidance literature:: With hydrogenchloride; sodium hydroxide; In ethanol; ethyl acetate;

Reference yield:

: ethyl 2-[6-[[3-[4-(diphenylmethoxy)piperidino]propyl]amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate difumarate

: 215529-47-8
2-[6-[[3-[4-(diphenylmethoxy)piperidino]propyl]amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 45 ℃; for 6h;
DOI:10.1248/cpb.51.122

Reference yield:

: 215530-63-5
ethyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate

: 215529-47-8
2-[6-[[3-[4-(diphenylmethoxy)piperidino]propyl]amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: nitrogen; sodium carbonate / ethanol; water; dimethyl sulfoxide; ethyl acetate

2: hydrogenchloride; sodium hydroxide / ethanol; ethyl acetate

With hydrogenchloride; sodium hydroxide; nitrogen; sodium carbonate; In ethanol; water; dimethyl sulfoxide; ethyl acetate;