ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

Base Information

Chemical Name:ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate
CAS No.:215529-43-4
Molecular Formula:C₃₃H₄₁N₅O₃
Molecular Weight:555.72
Hs Code.:

Synonyms:ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

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Chemical Property of ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

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Technology Process of ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

There total 6 articles about ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 215530-63-5
ethyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate

: 101620-72-8
1-(3-aminopropyl)-4-diphenylmethoxypiperidine

: 215529-43-4
ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

Guidance literature:: With sodium carbonate; In water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 63891-88-3
ethyl 4-bromo-2,2-dimethyl-3-oxobutanoate

: 215529-43-4
ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / Na₂HPO₄ / ethanol / 8 h / Heating

2: 65 percent / N-methyl-2-pyrrolidinone / 4.5 h / 191 - 195 °C

With 1-methyl-pyrrolidin-2-one; disodium hydrogenphosphate; In ethanol;
DOI:10.1248/cpb.51.122

Reference yield:

: 58258-01-8
4-diphenylmethoxypiperidine

: 215529-43-4
ethyl 2-[6-[3-[4-(diphenylmethoxy)piperidino]propyl-amino]imidazo[1,2-b]pyridazin-2-yl]-2-methylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 20 °C

2: NH₂NH₂*H₂O / ethanol / Heating

3: 65 percent / N-methyl-2-pyrrolidinone / 4.5 h / 191 - 195 °C

With 1-methyl-pyrrolidin-2-one; potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.51.122