4'-methylnicotine

Base Information

• Chemical Name: 4'-methylnicotine
• CAS No.: 74805-00-8
• Molecular Formula: C₁₁H₁₆N₂
• Molecular Weight: 176.261
• Mol file: 74805-00-8.mol

Synonyms:4’-methylnicotine

Chemical Property of 4'-methylnicotine

Chemical Property:

• Vapor Pressure: 0.0171mmHg at 25°C
• Boiling Point: 254.6°C at 760 mmHg
• Flash Point: 107.8°C
• PSA: 16.13000
• Density: 0.994g/cm³
• LogP: 2.03220

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-methylnicotine

There total 5 articles about 4'-methylnicotine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1,3-Dimethyl-5-pyridin-3-yl-pyrrolidin-2-one (74804-86-7) → 4'-Methylnicotine (74805-00-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Heating;

Reference yield:

cotinine (15569-85-4) → 4'-Methylnicotine (74805-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / sodium amide, iron(III) chloride / liquid ammonia; diethyl ether / -50 °C

2: 64 percent / lithium aluminium hydride / diethyl ether / 3 h / Heating

With lithium aluminium tetrahydride; iron(III) chloride; sodium amide; In diethyl ether; ammonia;

Reference yield:

ethyl N-methyl-N-<4-chloro-4-(3-pyridyl)butnyl>carbamate (73130-52-6) → 4'-Methylnicotine (74805-00-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / 10percent aq. sulphuric acid / 5 h / Heating; further reagent

2: 5 percent / silver nitrite / dimethylformamide / 70 °C

3: 59 percent / sodium amide, iron(III) chloride / liquid ammonia; diethyl ether / -50 °C

4: 64 percent / lithium aluminium hydride / diethyl ether / 3 h / Heating

With lithium aluminium tetrahydride; silver(I) nitrite; sulfuric acid; iron(III) chloride; sodium amide; In diethyl ether; ammonia; N,N-dimethyl-formamide;

upstream raw materials:

1,3-Dimethyl-5-pyridin-3-yl-pyrrolidin-2-one

cotinine

ethyl N-methyl-N-<4-chloro-4-(3-pyridyl)butnyl>carbamate

3-(1-methyl-pyrrolidin-2-yl)-pyridine

Refernces

• 1、 Acheson, R. Morrin,Ferris, Michael J.,Sinclair, Neil M.. "Transformations involving the Pyrrolidine Ring of Nicotine". . p. 579 - 585. Retrieved 2007/10/02.