AKOS BC-0123

Base Information

• Chemical Name: AKOS BC-0123
• CAS No.: 38948-28-6
• Molecular Formula: C13H21N3O
• Molecular Weight: 235.329
• Hs Code.: 2933599090
• Mol file: 38948-28-6.mol

Synonyms:TEDATIOXETINE;

Chemical Property of AKOS BC-0123

Chemical Property:

• PSA: 41.73000
• LogP: 1.35200

Purity/Quality:

97% ^*data from raw suppliers

4-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]ANILINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS BC-0123

There total 8 articles about AKOS BC-0123 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 4-(2-(4-methylpiperazin-1-yl)ethoxy)benzenamine (38948-28-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; under 2250.23 Torr;

Reference yield: 68.0%

1-methyl-4-[2-(4-nitrophenoxy)ethyl]piperazine → 4-(2-(4-methylpiperazin-1-yl)ethoxy)benzenamine (38948-28-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃;

Reference yield:

4-chlorobenzonitrile (100-00-5) → 4-(2-(4-methylpiperazin-1-yl)ethoxy)benzenamine (38948-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 69.1 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C

2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; dimethyl sulfoxide;

DOI:10.1248/cpb.30.3580

upstream raw materials:

1-Methyl-4-[2-(4-nitro-phenoxy)-ethyl]-piperazine; hydrochloride

2-(4-methylpiperazinyl)ethanol

4-chlorobenzonitrile

2-(4-nitrophenoxy)ethanol

Downstream raw materials:

{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenyl}-(7-pyridin-3-yl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine

5-{4-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-benzyl}-thiazolidine-2,4-dione; hydrochloride