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1-Chloro-4-nitrobenzene suppliers in China
Cas No: 100-00-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Cas No: 100-00-5
No Data 1 Metric Ton 1 Metric Ton/Day Hangzhou Keyingchem Co.,Ltd Contact Supplier
High quality 4-Chloronitrobenzene supplier in China
Cas No: 100-00-5
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
Cas No: 100-00-5
USD $ 2.0-3.0 / Metric Ton 1 Metric Ton 50 Metric Ton/Day EAST CHEMSOURCES LIMITED Contact Supplier
Factory Supply 1-chloro-4-nitrobenzene
Cas No: 100-00-5
No Data 1 1 Ality Chemical Corporation Contact Supplier
Cas No: 100-00-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
100-00-5 4-Chloronitrobenzene
Cas No: 100-00-5
USD $ 1000.0-1000.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
1-Chloro-4-nitrobenzene CAS 100-00-5 Pharmaceutical Raw Materials
Cas No: 100-00-5
No Data 100 Gram 20000 Kilogram/Day Hubei XinRunde Chemical Co., Ltd Contact Supplier
Lowest price Benzene,1-chloro-4-nitro- CAS:100-00-5
Cas No: 100-00-5
USD $ 0.3-0.85 / Gram 1 Gram 10 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Cas No: 100-00-5
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier

100-00-5 Usage

Chemical Properties

4-Chloronitrobenzene is a light yellow monoclinic prisms crystallizes, which are insoluble in water and very soluble in toluene, ether, acetone, or hot ethanol. It is incompatible with strong oxidizers and alkalis. It is extensively used in different industries as an intermediate in the manufacture of dyes, rubber, and agricultural chemicals.

Physical properties

p-Nitrochlorobenzene is a yellow crystalline solid with a sweet odor.


4-Nitrochlorobenzene is an important intermediate in the manufacture of azo dyes and sulfide dyes, the drugs finasteride and paracetamol, the pesticide herbicide, etc. It is also the raw material of rubber antioxidant 4010.


p-Nitrochlorobenzene is largely used to produce p-nitrophenol with smaller production of p-nitroaniline.


Manufacture of dyes, rubber, and agricultural chemicals


ChEBI: 4-Chloronitrobenzene is a C-nitro compound.

Production Methods

p-Nitrochlorobenzene is made by the nitration of chlorobenzene.

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 2407, 1987 DOI: 10.1021/jo00388a014Tetrahedron Letters, 19, p. 4519, 1978

General Description

Light yellow crystalline solid. Density 1.520 g / cm3. Melting point 83°C. Sweet odor. Very toxic by inhalation, ingestion, and skin absorption. p-Chloronitrobenzene is extensively used in different industries as an intermediate in the manufacture of dyes, rubber, and agricultural chemicals. It is incompatible with strong oxidisers and alkalis.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Chloronitrobenzene reacts with oxidizing agents. Reacts violently and finally explosively when added to a solution of sodium methoxide in methanol. . Unstable when heated.


A questionable carcinogen. Very toxic by inhalation and ingestion. Absorbed via skin. Combustible. Methemoglobinemia.

Health Hazard

Repeated exposure to high levels of p-chloronitrobenzene causes adverse health effects. The symptoms of toxicity include, but are not limited to, anoxia, unpleasant taste, anemia, methemoglobinemia, hematuria (blood in the urine), spleen, kidney, bone marrow changes, and reproductive effects. The target organs of p-chloronitrobenzene poisoning have been identifi ed as the blood, liver, kidneys, cardiovascular system, spleen, bone marrow, and reproductive system.

Fire Hazard

4-Chloronitrobenzene is combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. A poison by ingestion. Experimental reproductive effects. Mutation data reported. Flammable liquid when exposed to heat, sparks, or flame. May explode on heating. Potentially violent reaction with sodium methoxide. When heated to decomDosition it emits very toxic fumes of NOx and Cl-. See also other chloronitrobenzene entries and NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.

Potential Exposure

p-Nitrochlorobenzene (PNCB) is used as an intermediate in pesticide (parathion) manufacture, drug (phenacetin and acetaminophen) manufacture; and in dye making; rubber and antioxidant manufacture.


No increase in tumor incidence was seen in rats fed up to 1000 ppm in the diet for 2 years; in mice, results were equivocal, with high-dose animals showing an increase in vascular tumors and low-dose males showing an increase in liver tumors.6 The IARC has determined that there is inadequate evidence in experimental animals and humans for the carcinogenicity of chlorobenzenes.7

Environmental fate

Biological. Under aerobic conditions, the yeast Rhodosporidium sp. metabolized pchloronitrobenzene to 4-chloroacetanilide and 4-chloro-2-hydroxyacetanilide as final major metabolites. Intermediate compounds identified include 4-chloronitrosobenzene, 4-chlorophenylhydroxylamine, and 4-chloroaniline (Corbett and Corbett, 1981). Under continuous flow conditions involving feeding, aeration, settling, and reflux, a mixture of p-chloronitrobenzene and 2,4-dinitrochlorobenzene was reduced 61–70% after 8–13 d by Arthrobacter simplex, a microorganism isolated from industrial waste. A similar experiment was conducted using two aeration columns. One column contained A. simplex, the other a mixture of A. simplex and microorganisms isolated from soil (Streptomyces coelicolor, Fusarium sp., probably aquaeductum and Trichoderma viride). After 10 d, 89.5–91% of the nitro compounds was reduced. p-Chloronitrobenzene was reduced to 4-chloroaniline and six unidentified compounds (Bielaszczyk et al., 1967). Photolytic. An aqueous solution containing p-chloronitrobenzene and a titanium dioxide (catalyst) suspension was irradiated with UV light (λ >290 nm). 2-Chloro-5-nitrophenol was the only compound identified as a minor degradation product. Continued irradiation caused additional degradation yielding carbon dioxide, water, hydrochloric and nitric acids (Hustert et al., 1987). Irradiation of p-chloronitrobenzene in air and nitrogen produced 4-chloro-2-nitrophenol and 4- chlorophenol, respectively (Kanno and Nojima, 1979). Chemical. Although no products were identified, p-chloronitrobenzene (1.5 x 10-5 M) was reduced by iron metal (33.3 g/L acid washed 18–20 mesh) in a carbonate buffer (1.5 x 10-2 M) at pH 5.9 and 15 °C. Based on the pseudo-first-order disappearance rate of 0.0336/min, the half-life was 20.6 min (Agrawal and Tratnyek, 1996).


UN1578 Chloronitrobenzenes, solid or liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Crystallise the nitrobenzene from 95% EtOH (charcoal) and sublime it in vacuo. [Emmons JAm Chem Soc 76 3470 1954, Newman & Forrest J Am Chem Soc 69 1221 1947, Beilstein 5 IV 723.]


A strong oxidizer. Reacts violently with oxidizers, combustibles, alkalis, sodium methoxide; and reducing materials.

Waste Disposal

Incineration (816℃, 0.5 second for primary combustion; 1204℃, 1.0 second for secondary combustion). The formation of elemental chlorine can be prevented through injection of steam or methane into the combustion process. nitrogen oxides may be abated through the use of thermal or catalytic devices.

100-00-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A15396)  1-Chloro-4-nitrobenzene, 98+%    100-00-5 250g 184.0CNY Detail
Alfa Aesar (A15396)  1-Chloro-4-nitrobenzene, 98+%    100-00-5 1000g 417.0CNY Detail
Alfa Aesar (A15396)  1-Chloro-4-nitrobenzene, 98+%    100-00-5 5000g 1670.0CNY Detail
Sigma-Aldrich (45925)  1-Chloro-4-nitrobenzene  analytical standard 100-00-5 45925-250MG 411.84CNY Detail
Aldrich (C59122)  1-Chloro-4-nitrobenzene  99% 100-00-5 C59122-100G 232.83CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name 4-Chloronitrobenzene

1.2 Other means of identification

Product number -
Other names 1-chloro-4-nitrobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100-00-5 SDS

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Bioaugmentation of a 4-Chloronitrobenzene (cas 100-00-5) contaminated soil with Pseudomonas putida ZWL7307/27/2019

The strain Pseudomonas putida ZWL73, which metabolizes 4-chloronitrobenzene (4CNB) by a partial-reductive pathway, was inoculated into lab-scale 4CNB-contaminated soil for bioaugmentation purposes in this study. The degradation of 4CNB was clearly stimulated, as indicated with the gradual accumu...detailed

Biodegradation of 4-Chloronitrobenzene (cas 100-00-5) by biochemical cooperation between Sphingomonas sp. strain CNB3 and Burkholderia sp. strain CAN6 isolated from activated sludge07/26/2019

Two bacterial strains were isolated from activated sludge by using 4-chloronitrobenzene (4-CB) as the sole source of carbon for enrichment. One of the isolates was identified as Sphingomonas sp. strain CNB3 and the other as Burkholderia sp. strain CAN6, mainly through morphological and physiolog...detailed

Catalytic HDC/HDN of 4-Chloronitrobenzene (cas 100-00-5) in water under ambient-like conditions with Pd supported on pillared clay07/25/2019

Hydrotreatment of 4-chloronitrobenzene in aqueous phase has been carried out under ambient-like operating conditions (25 °C and 1 atm) with H2 using an own-prepared catalyst based on Pd (1 wt%) supported on Al-pillared clay. Nitrobenzene, 4-chloroaniline, aniline and cyclohexanone were identifi...detailed

The reduction of 4-Chloronitrobenzene (cas 100-00-5) by Fe(II)-Fe(III) oxide systems - correlations with reduction potential and inhibition by silicate07/22/2019

Recent studies have demonstrated that the rate at which Fe(II)-Fe(III) oxyhydroxide systems catalyze the reduction of reducible contaminants, such as 4-chloronitrobenzene, is well correlated to their thermodynamic reduction potential. Here we confirm this effect in the presence of Fe(III) oxyhyd...detailed

Reduction of 4-Chloronitrobenzene (cas 100-00-5) in a bioelectrochemical reactor with biocathode at ambient temperature for a long-term operation07/20/2019

In this study, the enhancement on 4-chloronitrobenzene (4-CNB) reduction was investigated in a dual-bioelectrochemical system with the cathode seeded by enriched 4-CNB degradation inoculums. We demonstrated that the biocathode had the ability to promote 4-CNB reduction and avoid more reluctant b...detailed

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In this study, Fe2+-modified goethite with low defects (α-Fe(Fe2+)OOH) was synthesized and characterized. Results revealed that α-Fe(Fe2+)OOH is a nano magnetic material with goethite (α-FeOOH) -type structures and has fewer Lewis acid of Fe3+ on its surface. Moreover, α-Fe(Fe2+)OOH was effe...detailed

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