2-Propenamide, N-[(1S)-2-[4-(4-chlorobenzoyl)-1-piperidinyl]-1-(hydroxymethyl)ethyl]-3-( 5-cyano-2-methoxyphenyl)-, (2E)-

Base Information

Chemical Name:2-Propenamide, N-[(1S)-2-[4-(4-chlorobenzoyl)-1-piperidinyl]-1-(hydroxymethyl)ethyl]-3-( 5-cyano-2-methoxyphenyl)-, (2E)-
CAS No.:389891-10-5
Molecular Formula:C26H28ClN3O4
Molecular Weight:481.979
Hs Code.:
Mol file:389891-10-5.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propenamide, N-[(1S)-2-[4-(4-chlorobenzoyl)-1-piperidinyl]-1-(hydroxymethyl)ethyl]-3-( 5-cyano-2-methoxyphenyl)-, (2E)-

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Technology Process of 2-Propenamide, N-[(1S)-2-[4-(4-chlorobenzoyl)-1-piperidinyl]-1-(hydroxymethyl)ethyl]-3-( 5-cyano-2-methoxyphenyl)-, (2E)-

There total 3 articles about 2-Propenamide, N-[(1S)-2-[4-(4-chlorobenzoyl)-1-piperidinyl]-1-(hydroxymethyl)ethyl]-3-( 5-cyano-2-methoxyphenyl)-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 389891-29-6
3'-cyano-6'-methoxycinnamic acid

: 389891-28-5
[1-((S)-2-Amino-3-hydroxy-propyl)piperidin-4-yl]-(4-chloro-phenyl)-methanone hydrochloride

: 125700-67-6
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

: 389891-10-5
(E)-N-{(S)-1-[4-(4-chlorobenzoyl)-piperidin-1-yl-methyl]-2-hydroxyethyl}-3-(5-cyano-2-methoxyphenyl)acrylamide

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 389891-34-3
(E)-3-(5-cyano-2-methoxyphenyl)thioacrylic acid S-benzothiazol-2-yl-thioester

: (2S)-2-amino-3-(4-(4￠-chlorobenzoyl)piperidin-1-yl)-1-propanol dihydrochloride

: 389891-10-5
(E)-N-{(S)-1-[4-(4-chlorobenzoyl)-piperidin-1-yl-methyl]-2-hydroxyethyl}-3-(5-cyano-2-methoxyphenyl)acrylamide

Guidance literature:: (2S)-2-amino-3-(4-(4￠-chlorobenzoyl)piperidin-1-yl)-1-propanol dihydrochloride; With 4-methyl-morpholine; In ethanol; at 20 - 45 ℃; for 0.5h;

(E)-3-(5-cyano-2-methoxyphenyl)thioacrylic acid S-benzothiazol-2-yl-thioester; In ethanol; at 45 ℃; Solvent; Concentration; Temperature; Time;
DOI:10.1021/op0601464