125700-67-6 Usage
Description
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, commonly known as TDB, is a white to pale cream fine crystalline powder that serves as a versatile coupling reagent in the field of organic chemistry. It is particularly useful in peptide synthesis, where it facilitates the formation of amide bonds with minimal racemization. TDB is also employed in the synthesis of various complex molecules, such as tetrapeptoid analogues and t-antigen glycodendrimers, due to its unique reactivity and stability.
Uses
Used in Pharmaceutical Synthesis:
TDB is used as a coupling reagent in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Its application in this field is crucial for the development of novel therapeutic agents with potential antiprotozoal properties.
Used in Glycodendrimer Synthesis:
TDB is utilized as a coupling reagent in the synthesis of acid-based t-antigen glycodendrimers. These complex molecules have potential applications in the fields of biology and medicine, particularly in the development of targeted drug delivery systems and vaccines.
Used in Peptide Synthesis:
TDB is used as a coupling reagent for peptide synthesis, causing low racemization. This property is highly desirable in the production of peptides, as racemization can lead to the formation of unwanted stereoisomers, which may have different or reduced biological activity. The use of TDB in peptide synthesis helps to maintain the desired stereochemistry and improve the overall yield of the target peptide.
Used in Solid-Phase Peptide Synthesis:
TDB is ideally suited for solid-phase peptide synthesis, a widely employed technique in the production of peptides and proteins. Its use in this context allows for the efficient and controlled assembly of peptide chains on an insoluble support, facilitating the synthesis of complex peptides with high purity and yield.
Check Digit Verification of cas no
The CAS Registry Mumber 125700-67-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,7,0 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 125700-67:
(8*1)+(7*2)+(6*5)+(5*7)+(4*0)+(3*0)+(2*6)+(1*7)=106
106 % 10 = 6
So 125700-67-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N5O.BF4/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
125700-67-6Relevant articles and documents
Modified iRNA agents
-
, (2016/04/20)
The present invention provides effective motifs for RNA agents conjugated to at least one ligand, which are advantageous for the in vivo delivery of iRNA duplex agents. Additionally, the present invention provides methods of making these compositions, as well as methods of introducing these iRNA duplex agents into cells using these compositions, e.g., for the treatment of various disease conditions.
Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
-
, (2008/06/13)
NPY-antagonistic compounds of the formula STR1 Exemplary are: (A) (R)-N-[[4-(Aminocarbonylaminomethyl)phenyl]methyl]-N 2-bis(4-hydroxyphenyl)acetyl]-argininamide-trifluoracetate;(B) (R)-N-[[4-(Aminocarbonylaminomethyl)phenyl]methyl]-N 2-[bis(4-chlorphenyl)acetyl]-argininamide-trifluoracetate;(C) (R)-N-[[4-Aminocarbonylaminomethyl)phenyl]methyl]-N 2-(diphenylacetyl)-argininamide-trifluoracetate;(D) (R)-N 2-(Diphenylacetyl)-N-[[4-(ethoxycarbonylmethylamino-carbonylaminomethyl) phenyl]methyl]-argininamide-trifluoroacetate;(E) (R,S)-N 5-(Aminoiminomethyl)-N 2-(diphenylacetyl)-N-[(4-hy-droxyphenyl)methyl]-N 5-methyl-ornithinamide-hydrochloride; (F) (R)-N-[[4-(Aminocarbonylmethyl)phenyl]methyl]-N 2-(diphenyl-acetyl)-argininamide-diacetate;(G) (R)-N. sup. 2-(Diphenylacetyl)-N-[[4-(ethylaminocarbonylamino-methyl)-phenyl]methyl]-argininamide-bis-(trifluoroacetate); and,(H) (R)-N. sup.2-(Diphenylacetyl)-N-[[4-(ethoxycarbonylamino-carbonylaminomethyl) phenyl]methyl]-argininamide-trifluoroacetate.
NEW COUPLING REAGENTS IN PEPTIDE CHEMISTRY
Knorr, Reinhard,Trzeciak, Arnold,Bannwarth, Willi,Gillessen, Dieter
, p. 1927 - 1930 (2007/10/02)
2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) has been applied as coupling reagent to solid phase peptide synthesis.Furthermore, a general synthetic procedure for new derivatives of different N-hydroxy compounds has been developed.They either act as excellent activating reagents causing low racemization during condensation of peptide segments or are useful tools for the formation of active esters suitable for couplings in mixed aqueous / organic media, respectively.