2-Hydroxy-5-iodonicotinic acid

Base Information

• Chemical Name: 2-Hydroxy-5-iodonicotinic acid
• CAS No.: 390360-97-1
• Molecular Formula: C6H4INO3
• Molecular Weight: 265.00500
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20445813
• Wikidata: Q82264340
• Mol file: 390360-97-1.mol

Synonyms:2-Hydroxy-5-iodonicotinic acid;390360-97-1;5-iodo-2-oxo-1H-pyridine-3-carboxylic Acid;2-hydroxy-5-iodopyridine-3-carboxylic acid;MFCD11100199;2-Hydroxy-5-iodonicotinicacid;SCHEMBL3982338;DTXSID20445813;AMY28768;AKOS005071606;AKOS015156549;AC-0201;SY081676;CS-0157378;C74987;A924546;J-509645

Chemical Property of 2-Hydroxy-5-iodonicotinic acid

Chemical Property:

• Melting Point: 264-266°
• PSA: 70.42000
• LogP: 1.09000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 264.92359
• Heavy Atom Count: 11
• Complexity: 280

Purity/Quality:

99%, ^*data from raw suppliers

2-Hydroxy-5-iodonicotinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=O)NC=C1I)C(=O)O

Technology Process of 2-Hydroxy-5-iodonicotinic acid

There total 1 articles about 2-Hydroxy-5-iodonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-hydroxy-3-carboxypyridine (609-71-2) → 2-hydroxy-5-iodonicotinic acid (390360-97-1)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 21h; Darkness;

DOI:10.1016/j.bmc.2015.05.047

Reference yield:

2-hydroxy-5-iodonicotinic acid (390360-97-1) → 5-Hydroxy-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propylamino}-N,N-dimethyl-nicotinamide

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂, DMF / 3 h / Heating

2: Et₃N / 1,2-dichloro-ethane / 0.25 h / 0 °C

3: 1.) t-BuLi, 2.) (-)-(10-camphorsulfonyl)oxaziridine / 1.) THF, -90 deg C, 10 min, 2.) THF, -90 deg C, 10 min

4: 78 percent / (i-Pr)2NEt / CH₂Cl₂ / 14 h / Ambient temperature

5: K₂CO₃ / xylene / 20 h / Heating

With thionyl chloride; tert.-butyl lithium; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; (-)-(1R)-(10-camphorsulfonyl)oxaziridine; In dichloromethane; 1,2-dichloro-ethane; xylene;

DOI:10.1021/jm970166j

Reference yield:

2-hydroxy-5-iodonicotinic acid (390360-97-1) → 5-Cyano-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propylamino}-N,N-dimethyl-nicotinamide

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂, DMF / 3 h / Heating

2: Et₃N / 1,2-dichloro-ethane / 0.25 h / 0 °C

3: 54 percent / 12-crown-4, (Ph₃P)4Pd / benzene / 168 h / 50 °C

4: K₂CO₃ / xylene / 20 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; (1,4,7,10-tetraoxacyclododecane); potassium carbonate; triethylamine; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; xylene; benzene;

DOI:10.1021/jm970166j

upstream raw materials:

2-hydroxy-3-carboxypyridine

Downstream raw materials:

2-chloro-5-iodonicotinic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 390360-97-1 2-hydroxy-5-iodonicotinic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send