1-BOC-3-(3,4-DICHLOROPHENYL)-3-HYDROXYPYRROLIDINE

Base Information

Chemical Name:1-BOC-3-(3,4-DICHLOROPHENYL)-3-HYDROXYPYRROLIDINE
CAS No.:390406-53-8
Molecular Formula:C15H19Cl2NO3
Molecular Weight:332.227
Hs Code.:
Mol file:390406-53-8.mol

Synonyms:tert-butyl 3-(3,4-dichlorophenyl)-3-hydroxypyrrolidin-1-carboxylate;3-(3,4-Dichloro-phenyl)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester;

Suppliers and Price of 1-BOC-3-(3,4-DICHLOROPHENYL)-3-HYDROXYPYRROLIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
1-Boc-3-(3,4-dichlorophenyl)-3-pyrrolidinol 97%
1g
$ 495.00

Acrotein
1-Boc-3-(3,4-dichlorophenyl)-3-pyrrolidinol 97%
0.5g
$ 330.00

ACHEMBLOCK
1-Boc-3-(3,4-dichlorophenyl)-3-pyrrolidinol 95%
250MG
$ 270.00

Total 2 raw suppliers

Chemical Property of 1-BOC-3-(3,4-DICHLOROPHENYL)-3-HYDROXYPYRROLIDINE

Chemical Property:

PSA：49.77000
LogP:3.75970

Purity/Quality:

95%-98% ^*data from raw suppliers

1-Boc-3-(3,4-dichlorophenyl)-3-pyrrolidinol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-BOC-3-(3,4-DICHLOROPHENYL)-3-HYDROXYPYRROLIDINE

There total 5 articles about 1-BOC-3-(3,4-DICHLOROPHENYL)-3-HYDROXYPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18282-59-2
4-bromo-1,2-dichlorobenzene

: 101385-93-7
3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 390406-53-8
tert-butyl 3-(3,4-dichlorophenyl)-3-hydroxypyrrolidine-1-carboxylate

Guidance literature:: 4-bromo-1,2-dichlorobenzene; With magnesium; In tetrahydrofuran; for 1h; Heating / reflux;

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester; In tetrahydrofuran; at 20 ℃; for 3h; Heating / reflux;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 20555-91-3
3,4-dichloroiodobenzene

: 101385-93-7
3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 390406-53-8
tert-butyl 3-(3,4-dichlorophenyl)-3-hydroxypyrrolidine-1-carboxylate

Guidance literature:: 3,4-dichloroiodobenzene; With n-butyllithium; In diethyl ether; at -78 ℃;

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester; In diethyl ether;
DOI:10.1016/S0960-894X(01)00538-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 390406-53-8
tert-butyl 3-(3,4-dichlorophenyl)-3-hydroxypyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂

2.1: SO₃*pyridine; Et₃N / CH₂Cl₂

3.1: n-BuLi / diethyl ether / -78 °C

3.2: diethyl ether

With n-butyllithium; pyridine-SO₃ complex; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(01)00538-8