1H-Benzimidazole-4-carboxamide, N-[4-[[[[(2S)-2-(3,4-dichlorophenyl)-2-hydroxyethyl](1-methylethyl)amino] carbonyl]amino]phenyl]-

Base Information

Chemical Name:1H-Benzimidazole-4-carboxamide, N-[4-[[[[(2S)-2-(3,4-dichlorophenyl)-2-hydroxyethyl](1-methylethyl)amino] carbonyl]amino]phenyl]-
CAS No.:390406-77-6
Molecular Formula:C₂₆H₂₅Cl₂N₅O₃
Molecular Weight:526.422
Hs Code.:
Mol file:390406-77-6.mol

Synonyms:

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Chemical Property of 1H-Benzimidazole-4-carboxamide, N-[4-[[[[(2S)-2-(3,4-dichlorophenyl)-2-hydroxyethyl](1-methylethyl)amino] carbonyl]amino]phenyl]-

Chemical Property:

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Technology Process of 1H-Benzimidazole-4-carboxamide, N-[4-[[[[(2S)-2-(3,4-dichlorophenyl)-2-hydroxyethyl](1-methylethyl)amino] carbonyl]amino]phenyl]-

There total 6 articles about 1H-Benzimidazole-4-carboxamide, N-[4-[[[[(2S)-2-(3,4-dichlorophenyl)-2-hydroxyethyl](1-methylethyl)amino] carbonyl]amino]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 71026-66-9
N-(tert-butoxycarbonyl)-1,4-phenylenediamine

: 390406-77-6
1H-benzoimidazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenyl)-2-hydroxy-ethyl]-3-isopropyl-ureido}-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: HCl / ethyl acetate

3: EDC; HOAt / dimethylformamide

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00538-8

Reference yield:

: 2632-10-2
2-bromo-1-(3,4-dichlorophenyl)ethanone

: 390406-77-6
1H-benzoimidazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenyl)-2-hydroxy-ethyl]-3-isopropyl-ureido}-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: (+)-DIP-chloride / tetrahydrofuran / 0 °C

2: 60 °C

3: Et₃N / CH₂Cl₂

4: HCl / ethyl acetate

5: EDC; HOAt / dimethylformamide

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; B-chlorodiisopinocampheylborane; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00538-8

Reference yield:

: 20879-18-9
(+)-Dichloroisoproterenol

: 390406-77-6
1H-benzoimidazole-4-carboxylic acid (4-{3-[2-(3,4-dichloro-phenyl)-2-hydroxy-ethyl]-3-isopropyl-ureido}-phenyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: HCl / ethyl acetate

3: EDC; HOAt / dimethylformamide

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00538-8