2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-(acetyloxy)-10-(3-furanyl)-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-(acetyloxy)-10-(3-furanyl)-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester
CAS No.:390748-01-3
Molecular Formula:C25H30N2O7S
Molecular Weight:502.588
Hs Code.:
Mol file:390748-01-3.mol

Synonyms:

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Chemical Property of 2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-(acetyloxy)-10-(3-furanyl)-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester

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Technology Process of 2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-(acetyloxy)-10-(3-furanyl)-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester

There total 15 articles about 2,7-Diazaspiro[4.5]dec-9-ene-2-carboxylic acid, 1-(acetyloxy)-10-(3-furanyl)-7-(phenylsulfonyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 390748-01-3
1-acetoxy-7-benzenesulfonyl-10-furan-3-yl-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 63 percent / Et₃N; DMAP

2.1: LiN(TMS)2 / tetrahydrofuran / -65 °C

2.2: 50 percent / 3 °C

3.1: LiCl; Na₂CO₃ / Pd(Ph₃P)4 / H₂O; 1,2-dimethoxy-ethane / 3 h / 80 °C

4.1: DIBAL / toluene / -65 - 20 °C

5.1: pyridine

With pyridine; dmap; diisobutylaluminium hydride; sodium carbonate; triethylamine; lithium chloride; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;
DOI:10.1016/S0040-4039(01)01792-0

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 390748-01-3
1-acetoxy-7-benzenesulfonyl-10-furan-3-yl-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: NaHCO₃

2.1: K₂CO₃

3.1: p-TsOH

4.1: 53 percent / OsO₄; NaIO₄ / tetrahydrofuran; H₂O

5.1: AcOH / methanol / 1 h / 20 °C

6.1: NaBH₃CN / 2 h / Heating

7.1: CAN / acetonitrile; H₂O / 20 °C

8.1: HClO₄ / CH₂Cl₂; H₂O

9.1: 63 percent / Et₃N; DMAP

10.1: LiN(TMS)2 / tetrahydrofuran / -65 °C

10.2: 50 percent / 3 °C

11.1: LiCl; Na₂CO₃ / Pd(Ph₃P)4 / H₂O; 1,2-dimethoxy-ethane / 3 h / 80 °C

12.1: DIBAL / toluene / -65 - 20 °C

13.1: pyridine

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; perchloric acid; ammonium cerium(IV) nitrate; diisobutylaluminium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; lithium chloride; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/S0040-4039(01)01792-0

Reference yield:

: 566905-25-7
methyl 4-hydroxy-1-phenylsulfonyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate

: 390748-01-3
1-acetoxy-7-benzenesulfonyl-10-furan-3-yl-2,7-diaza-spiro[4.5]dec-9-ene-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: K₂CO₃

2.1: p-TsOH

3.1: 53 percent / OsO₄; NaIO₄ / tetrahydrofuran; H₂O

4.1: AcOH / methanol / 1 h / 20 °C

5.1: NaBH₃CN / 2 h / Heating

6.1: CAN / acetonitrile; H₂O / 20 °C

7.1: HClO₄ / CH₂Cl₂; H₂O

8.1: 63 percent / Et₃N; DMAP

9.1: LiN(TMS)2 / tetrahydrofuran / -65 °C

9.2: 50 percent / 3 °C

10.1: LiCl; Na₂CO₃ / Pd(Ph₃P)4 / H₂O; 1,2-dimethoxy-ethane / 3 h / 80 °C

11.1: DIBAL / toluene / -65 - 20 °C

12.1: pyridine

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; perchloric acid; ammonium cerium(IV) nitrate; diisobutylaluminium hydride; sodium cyanoborohydride; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; lithium chloride; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/S0040-4039(01)01792-0