Technology Process of 1,7-Octadien-4-ol,
6-[(4-methoxyphenyl)methoxy]-3,5,7-trimethyl-8-(2-methyl-4-oxazolyl)-,
(3S,4S,5R,6R,7E)-
There total 6 articles about 1,7-Octadien-4-ol,
6-[(4-methoxyphenyl)methoxy]-3,5,7-trimethyl-8-(2-methyl-4-oxazolyl)-,
(3S,4S,5R,6R,7E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
trans-2-Butene;
With
n-butyllithium; potassium tert-butylate;
In
tetrahydrofuran; hexane;
at -78 - -45 ℃;
for 0.25h;
(2S,3R,4E)-3-(4-methoxybenzyloxy)-2,4-dimethyl-5-(2-methyloxazol-4-yl)pent-4-enal;
With
boron trifluoride diethyl etherate; (-)-B-methoxydiisopinocampheylborane;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 22h;
DOI:10.1039/c2ob25766a
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 93 percent / benzene / 18 h / 80 °C / Heating
2.1: t-BuOK; n-BuLi; (+)-(Ipc)2BOMe / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 67 percent / BF3*Et2O / tetrahydrofuran; hexane / 6 h / -71 °C
3.1: NaH / tetrahydrofuran / 0.67 h / Heating
3.2: 89 percent / n-Bu4NI / tetrahydrofuran / 6 h / Heating
4.1: 84 percent / H2O; N-methylmorpholine-N-oxide; OsO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 10 h / 20 °C
5.1: 98 percent / NaIO4; H2O / tetrahydrofuran / 0.5 h / 20 °C
6.1: t-BuOK; n-BuLi; (-)-(Ipc)2BOMe / tetrahydrofuran; hexane / 0.5 h / -78 °C
6.2: 53 percent / BF3*Et2O / tetrahydrofuran; hexane / 19 h / -78 °C
With
sodium periodate; osmium(VIII) oxide; n-butyllithium; potassium tert-butylate; water; sodium hydride; 4-methylmorpholine N-oxide; (-)-B-methoxydiisopinocampheylborane; (+)-B-methoxydiisocamphenylborane;
In
tetrahydrofuran; hexane; tert-butyl alcohol; benzene;
1.1: Wittig reaction;
DOI:10.1021/ol010193a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: t-BuOK; n-BuLi; (+)-(Ipc)2BOMe / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 67 percent / BF3*Et2O / tetrahydrofuran; hexane / 6 h / -71 °C
2.1: NaH / tetrahydrofuran / 0.67 h / Heating
2.2: 89 percent / n-Bu4NI / tetrahydrofuran / 6 h / Heating
3.1: 84 percent / H2O; N-methylmorpholine-N-oxide; OsO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 10 h / 20 °C
4.1: 98 percent / NaIO4; H2O / tetrahydrofuran / 0.5 h / 20 °C
5.1: t-BuOK; n-BuLi; (-)-(Ipc)2BOMe / tetrahydrofuran; hexane / 0.5 h / -78 °C
5.2: 53 percent / BF3*Et2O / tetrahydrofuran; hexane / 19 h / -78 °C
With
sodium periodate; osmium(VIII) oxide; n-butyllithium; potassium tert-butylate; water; sodium hydride; 4-methylmorpholine N-oxide; (-)-B-methoxydiisopinocampheylborane; (+)-B-methoxydiisocamphenylborane;
In
tetrahydrofuran; hexane; tert-butyl alcohol;
DOI:10.1021/ol010193a
