1-(2-Chloroethyl)-4-Methylpiperazine

Base Information

• Chemical Name: 1-(2-Chloroethyl)-4-Methylpiperazine
• CAS No.: 39123-20-1
• Molecular Formula: C7H15ClN2
• Molecular Weight: 162.662
• Hs Code.: 2933599090
• Mol file: 39123-20-1.mol

Synonyms:2-(4-methylpiperazinyl)benzoic acid;N-(2-chloroethyl)-N'-methylpiperazine;2-(4-methyl-1-piperazinyl)benzoic acid;1-methyl-4-(2-chloroethyl)-piperazine;N-(CICH2CH2)-N'-Me-piperazine;2-(4-methyl-1-piperazinyl)-ethyl chloride;1-(4-methyl-1-piperazinyl)-2-chloroethane;

Chemical Property of 1-(2-Chloroethyl)-4-Methylpiperazine

Chemical Property:

• PSA: 6.48000
• LogP: 0.34840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(2-chloroethyl)-4-methylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-Chloroethyl)-4-Methylpiperazine

There total 11 articles about 1-(2-Chloroethyl)-4-Methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-methyl-piperazine (109-01-3) + 1-Bromo-2-chloroethane (107-04-0) → 1-(2-chloroethyl)-4-methylpiperazine (39123-20-1)

Guidance literature:

With sodium hydroxide; In acetone; at 20 ℃; for 48h;

Reference yield: 43.0%

1-methyl-piperazine (109-01-3) + 2-bromoethanol (540-51-2) → 1-(2-chloroethyl)-4-methylpiperazine (39123-20-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 75 ℃; for 16h;

DOI:10.1016/j.ejmech.2020.112295

Reference yield: 35.0%

2-(4-methylpiperazinyl)ethanol (5464-12-0) → 1-(2-chloroethyl)-4-methylpiperazine (39123-20-1)

Guidance literature:

With thionyl chloride; In chloroform; for 4h; Reflux;

upstream raw materials:

2-(4-methylpiperazinyl)ethanol

1-methyl-piperazine

1-Bromo-2-chloroethane

2-chloroethanal

Downstream raw materials:

10-[2-(4-methyl-piperazin-1-yl)-ethyl]-10H-phenothiazine

4-(4-methylpiperazin-1-yl)-2,2-diphenylbutanenitrile

N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-(4-methylpiperazin-1-yl)ethoxy>phenyl>methyl>hexanamide

8-methyl-7-<2-(4-methyl-1-piperazinyl)ethoxy>-2-(4-morpholinyl)-4H-1-benzopyran-4-one