2-(Chloromethyl)-5-methoxy-1,3,4-thiadiazole

Base Information

• Chemical Name: 2-(Chloromethyl)-5-methoxy-1,3,4-thiadiazole
• CAS No.: 3914-44-1
• Molecular Formula: C4H5ClN2OS
• Molecular Weight: 164.615
• Hs Code.: 2934999090
• Mol file: 3914-44-1.mol

Synonyms:2-Chlormethyl-5-methoxy-1,3,4-thiadiazol;2-(chloromethyl)-5-(methylsulfonyl)pyridine;2-Methoxy-5-chlormethyl-1,3,4-thiadiazol;2-chloromethyl-5-methoxy-[1,3,4]thiadiazole;2-chloromethyl-5-methanesulfonyl-pyridine;

Chemical Property of 2-(Chloromethyl)-5-methoxy-1,3,4-thiadiazole

Chemical Property:

• PSA: 63.25000
• LogP: 1.28550

Purity/Quality:

97% ^*data from raw suppliers

2-(chloromethyl)-5-methoxy-1,3,4-thiadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Chloromethyl)-5-methoxy-1,3,4-thiadiazole

There total 3 articles about 2-(Chloromethyl)-5-methoxy-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl chloroacetimidate hydrochloride (36743-66-5) + methyl imidothiocarbamate (19692-07-0) → 2-(chloromethyl)-5-methoxy-1,3,4-thiadiazole (3914-44-1)

Guidance literature:

In 1,4-dioxane; 1.) r.t., 3-4 h; 2.) reflux, overnight;

DOI:10.1002/hlca.19820650833

Reference yield:

N'-chloroacetyl-hydrazinecarbothioic acid O-methyl ester (3914-43-0) → 2-(chloromethyl)-5-methoxy-1,3,4-thiadiazole (3914-44-1)

Guidance literature:

With sulfuric acid; at 0 ℃;

DOI:10.1002/hlca.19720550616

Reference yield:

→ 2-(chloromethyl)-5-methoxy-1,3,4-thiadiazole (3914-44-1)

Guidance literature:

aus CH3O-C(=S)-NH-NH-CO-CH2Cl;

upstream raw materials:

N'-chloroacetyl-hydrazinecarbothioic acid O-methyl ester

ethyl chloroacetimidate hydrochloride

methyl imidothiocarbamate

Downstream raw materials:

thiophosphoric acid O,O'-diethyl ester S-(5-methoxy-[1,3,4]thiadiazol-2-ylmethyl) ester