19692-07-0

Basic information

• Product Name: hydrazinecarbothioic acid O-methyl ester
• Synonyms: hydrazinecarbothioic acid O-methyl ester;hydrazinomethanethioic acid O-methyl ester;O-methyl hydrazinecarbothioate;O-methyl hydrazinomethanethioate;O-methyl hydrazinylmethanethioate;Thiocarbazic acid O-methyl ester
• CAS NO: 19692-07-0
• Molecular Formula: C₂H₆N₂OS
• Molecular Weight: 106.15
• Mol File: 19692-07-0.mol

Chemical Properties

• Melting Point: 72-74 °C
• Boiling Point: 142.0±23.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO, Methanol (Slightly)
• PKA: 9.93±0.70(Predicted)
• Stability: Stench
• CAS DataBase Reference: hydrazinecarbothioic acid O-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: hydrazinecarbothioic acid O-methyl ester(19692-07-0)
• EPA Substance Registry System: hydrazinecarbothioic acid O-methyl ester(19692-07-0)

Safety Data

• Hazardous Substances Data: 19692-07-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
Hydrazinecarbothioic acid O-methyl ester is used as a reagent for the synthesis of methidathion, an insecticide. It plays a crucial role in the chemical reactions that lead to the formation of methidathion, which is an effective agent for controlling pests in agricultural settings.
In the chemical industry, hydrazinecarbothioic acid O-methyl ester is utilized as a building block for creating various organic compounds. Its reactivity and functional groups make it suitable for use in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 19708-81-7 methyl O-methyldithiocarbonate 
• 16323-12-9 2-(methoxycarbonothioylthio)acetic acid 
• 2667-20-1 potassium methylxanthate 
• 75-15-0 carbon disulfide 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 6370-03-2 sodium methyl xanthate 

Downstream Products

• 25996-54-7 N'-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-hydrazinecarbothioic acid O-methyl ester 
• 25996-56-9 N'-[1-(2-Chloro-phenyl)-meth-(Z)-ylidene]-hydrazinecarbothioic acid O-methyl ester 
• 13750-22-6 C₉H₁₂N₂O₃S₂ 
• 40401-97-6 C₁₀H₁₅N₂O₂PS₂ 
• 64273-26-3 6-methyl-5-phenyl-3,6-dihydro-[1,3,4]thiadiazin-2-one 
• 64273-23-0 5-phenyl-3,6-dihydro-[1,3,4]thiadiazin-2-one 
• 16841-84-2 2-amino-5-methoxy-1,3,4-thiadiazole 
• 37158-90-0 5-Methoxy-1,3,4-thiadiazol-2(3H)-on 
• 17605-27-5 5-methoxy-3H-[1,3,4]thiadiazol-2-one 
• 126725-03-9 1,4-bis(2,3-dihydro-6-methyl-2-oxo-6H-thiadiazin-5-yl)benzene 
• 1925-76-4 2-Methoxy-5-methyl-1,3,4-thiadiazol 
• 84389-19-5 2-Cyanmethyl-5-methoxy-1,3,4-thiadiazol 
• 84353-03-7 2-Isopropyl-5-methoxy-1,3,4-thiadiazol 
• 3914-44-1 2-(chloromethyl)-5-methoxy-1,3,4-thiadiazole 

Relevant articles and documents

COMPOUNDS, THEIR PREPARATION, RELATED COMPOSITIONS, CATALYSTS, ELECTROCHEMICAL CELLS, FUEL CELLS, AND USES THEREOF

In some embodiments, this application relates to inventive compounds (e.g., Formula (I), Formula (II), thiosemicarbazones and/or thiosemicarbazones and their metal (e.g., zinc, cobalt, nickel, or copper) complexes, and extended structures thereof), methods for preparation of the inventive compounds, compositions comprising the inventive compounds (e.g., anode, cathodes, catalysts (e.g., electrocatalysts), glassy carbon electrodes, carbon paste electrodes, covalently modified carbon (e.g., modified graphene)), electrochemical cells comprising compositions that comprise one or more inventive compounds, fuel cells comprising compositions that comprise one or more inventive compounds, uses of one or more inventive compounds to produce H2 (e.g., via an electrochemical cell), and uses of one or more inventive compounds to create energy from H2 (e.g., via a fuel cell). Additional embodiments of the invention are also discussed herein.

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy

In an effort to identify novel antithrombotics, we have investigated protease-activated receptor 4 (PAR4) antagonism by developing and evaluating a tool compound, UDM-001651, in a monkey thrombosis model. Beginning with a high-throughput screening hit, we identified an imidazothiadiazole-based PAR4 antagonist chemotype. Detailed structure-activity relationship studies enabled optimization to a potent, selective, and orally bioavailable PAR4 antagonist, UDM-001651. UDM-001651 was evaluated in a monkey thrombosis model and shown to have robust antithrombotic efficacy and no prolongation of kidney bleeding time. This combination of excellent efficacy and safety margin strongly validates PAR4 antagonism as a promising antithrombotic mechanism.

Syntheses, structures, and electrochemical studies of N,N′-bis(alkylthiocarbamate)butane-2,3-diimine Cu(II) complexes as pendent alkoxy derivatives of Cu(ATSM)

A series of N2S2-Cu(II) complexes based on N,N′-bis(alkylthiocarbamate)butane-2,3-diimine ligands have been synthesized and characterized by spectroscopic, electrochemical, and single crystal X-ray diffraction methods. This class of ligands contains a conjugated N2S2chelate framework with a non-coordinating, terminal alkoxy (–OR) group. Ligands and Cu(II) complexes were investigated for R = Me, Et,nPr,iPr, and octyl. Additionally, N,N′-bis(ethylthiocarbamate)hexane-3,4-diimine and its Cu(II) complex were analyzed. Single crystal X-ray diffraction studies on all six Cu(II) complexes confirm a square planar Cu(II) environment with no significant changes in the core structure as a function of R. Spectroscopic studies are consistent with a similar electronic environment in all complexes. However, electrochemical investigations reveal significant shifts in the CuII/Iand CuIII/IIreduction potentials throughout the series. The complexes are analogues of the well-known bis(thiosemicarbazone) Cu(II) which contain a similar donor core with terminal, non-coordinating amines. Substitution of the terminal amines of bis(thiosemicarbazones) with the alkoxy groups of N,N′-bis(alkylthiocarbamate)butane-2,3-diimines allows tuning of redox potentials with minimal changes in the physical and electronic structure.

Synthesis and biological activities of novel 1,3,4-thiadiazole-containing pyrazole oxime derivatives

A new library of 1,3,4-thiadiazole-containing pyrazole oximes was designed and synthesized. Their acaricidal and insecticidal activities were evaluated. Bioassay results indicated that some target compounds exhibited good acaricidal and insecticidal properties. Especially, compound 8m had 80% acaricidal activity against Tetranychus cinnabarinus at the concentration of 50?μg/mL, compound 8f displayed 100% insecticidal activities against Aphis craccivora at the concentration of 50?μg/mL, compounds 8r and 8w showed 100% insecticidal activities against Plutella xylostella at the concentration of 50?μg/mL. Furthermore, compounds 8r (LC50?=?19.61?μg/mL) and 8w (LC50?=?9.78?μg/mL) possessed comparable or even better insecticidal activities than the control Pyridalyl (LC50?=?17.40?μg/mL) against P. xylostella.

A thiadiazole compounds and its synthetic method

The invention relates to a thiadiazole compound and a synthesis method thereof. Alkoxy sodium xanthate is synthesized from an alcohol compound, sodium hydroxide and carbon disulfide, alkoxy thiocarbonyl hydrazine is synthesized from alkoxy sodium xanthate and hydrazine hydrate, and N'-alkoxyl thiocarbonyl-N-2-chloroacetylhydrazide is synthesized from alkoxy thiocarbonyl hydrazine and 2-chloroacetyl chloride; 2-alkoxyl-5-chloromethyl-1,3,4-thiadiazole is synthesized through cyclization of the generated hydrazide compound under an action of concentrated sulfuric acid and then undergoes a reaction with 4,5-dichloro-3(2H)pyridazinone, and the generated intermediate undergoes a substitution reaction with aliphatic amine or cyclic aliphatic amine or propyl sulfhydrate under catalysis of an alkaline reagent to synthesize a bishydrazide derivative. Compared with the prior art, the thiadiazole compound has the advantages of simple technological process and wide application range, is suitable for use in prevention and treatment of sanitary pests such as flies, mosquitoes, fleas and the like and prevention and treatment of other agricultural pests such as rice water weevils, beet armyworm, plutella xylostella, armyworm and the like, and is an insecticide having an application prospect.