Glycine, N-[(2,5-difluorophenyl)methyl]-N-[[4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[( methylsulfonyl)amino]phenyl]ethyl]amino]-1-piperidinyl]phenyl]sulfonyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Glycine, N-[(2,5-difluorophenyl)methyl]-N-[[4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[( methylsulfonyl)amino]phenyl]ethyl]amino]-1-piperidinyl]phenyl]sulfonyl]-, 1,1-dimethylethyl ester
• CAS No.: 391934-74-0
• Molecular Formula: C33H42F2N4O8S2
• Molecular Weight: 724.847

Synonyms:

Chemical Property of Glycine, N-[(2,5-difluorophenyl)methyl]-N-[[4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[( methylsulfonyl)amino]phenyl]ethyl]amino]-1-piperidinyl]phenyl]sulfonyl]-, 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of Glycine, N-[(2,5-difluorophenyl)methyl]-N-[[4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[( methylsulfonyl)amino]phenyl]ethyl]amino]-1-piperidinyl]phenyl]sulfonyl]-, 1,1-dimethylethyl ester

There total 2 articles about Glycine, N-[(2,5-difluorophenyl)methyl]-N-[[4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[( methylsulfonyl)amino]phenyl]ethyl]amino]-1-piperidinyl]phenyl]sulfonyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

tert-Butyl 2-((2,5-difluorobenzyl){[4-(4-oxo-1-piperidinyl)phenyl]-sulfonyl}amino)acetate (391935-84-5) + N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (340756-75-4) → tert-Butyl {(2,5-difluorobenzyl)[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]piperidin-1-yl}phenyl)sulfonyl]amino}acetate (391934-74-0)

Guidance literature:

Reference yield:

tert-butyl 2-({[4-(4-oxo-1-piperidinyl)phenyl]sulfonyl}amino)acetate (391935-70-9) + 2-(bromomethyl)-1,4-difluorobenzene (85117-99-3) → tert-Butyl {(2,5-difluorobenzyl)[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]piperidin-1-yl}phenyl)sulfonyl]amino}acetate (391934-74-0)

Guidance literature:

In N,N-dimethyl-formamide; mineral oil;

Reference yield: 42.0%

tert-Butyl {(2,5-difluorobenzyl)[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]piperidin-1-yl}phenyl)sulfonyl]amino}acetate (391934-74-0) → 2-{(2,5-Difluorobenzyl)[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}phenyl)sulfonyl]amino}acetic acid (391934-67-1)

Guidance literature:

upstream raw materials:

tert-butyl 2-({[4-(4-oxo-1-piperidinyl)phenyl]sulfonyl}amino)acetate

2-(bromomethyl)-1,4-difluorobenzene

tert-Butyl 2-((2,5-difluorobenzyl){[4-(4-oxo-1-piperidinyl)phenyl]-sulfonyl}amino)acetate

N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide

Downstream raw materials:

2-{(2,5-Difluorobenzyl)[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}phenyl)sulfonyl]amino}acetic acid

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