85117-99-3

Basic information

• Product Name: 2,5-Difluorobenzyl bromide
• Synonyms: 2,5-DIFLUOROBENZYL BROMIDE;ALPHA-BROMO-2,5-DIFLUOROTOLUENE;TIMTEC-BB SBB006680;2-(Bromomethyl)-1,4-difluorobenzene;Benzene, 2-(bromomethyl)-1,4-difluoro-;à-bromo-2,5-difluorotoluene;α-bromo-2,5-difluorotoluene;2,5-Difluorobenzyl bromide 98%
• CAS NO: 85117-99-3
• Molecular Formula: C₇H₅BrF₂
• Molecular Weight: 207.02
• EINECS: 285-651-0
• Product Categories: Fluoro-contained benzyl bromide series;Benzhydrols, Benzyl & Special Alcohols;Miscellaneous;Fluorinated benzene series;Fluorine series
• Mol File: 85117-99-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 28 °C
• Flash Point: 60 °F
• Appearance: Clear yellow liquid
• Density: 1.609 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.849mmHg at 25°C
• Refractive Index: n20/D 1.526(lit.)
• Storage Temp.: Flammables area
• BRN: 7089248
• CAS DataBase Reference: 2,5-Difluorobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Difluorobenzyl bromide(85117-99-3)
• EPA Substance Registry System: 2,5-Difluorobenzyl bromide(85117-99-3)

Safety Data

• Hazard Codes: F,C,Xi
• Statements: 11-34-22-36
• Safety Statements: 26-36/37/39-45-16
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 85117-99-3(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR YELLOW LIQUID

Uses

2,5-Difluorobenzyl bromide has been used in the synthesis of:novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors, for the potential treatment of Alzheimer′s diseasesulfonamide, amide and acyclic amine derivatives

InChI:InChI=1/C7H5BrF2/c8-4-5-3-6(9)1-2-7(5)10/h1-3H,4H2

Upstream product

• 452-67-5 1,4-difluoro-2-methylbenzene 
• 75853-20-2 2,5-difluoro-benzyl alcohol 

Downstream Products

• 101155-09-3 6-chloro-9-(2,5-difluorobenzyl)-9H-purine 
• 188439-66-9 methyl-1-(phenoxycarbonyl)-4-(2,5-difluorobenzyl)-1,4-dihydronicotinate 
• 64134-17-4 Diethyl-α-(2,5-difluorobenzyl)-α-acetamidomalonate 
• 308142-39-4 8-cyano-1-(2,5-difluoro-benzyl)-7-(4-isobutoxy-phenyl)-6-methyl-4-oxo-1,4-dihydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid ethyl ester 
• 837430-10-1 (2R,5S)-2,5-dihydro-3,6-dimethoxy-2-[(2',5'-difluorophenyl)methyl]-5-isopropylpyrazine 
• 470716-52-0 2-[[(4-chlorophenyl)thio]methyl]-1,4-difluorobenzene 
• 616881-83-5 N-tert-butoxycarbonylamino-O-(2,5-difluorobenzyl)-D-serine 
• 886060-99-7 1,4-difluoro-2-({[4-(trifluoromethyl)phenyl]thio}methyl)benzene 
• 705966-17-2 2,5-difluorobenzyl phenyl sulfone 
• 632626-68-7 3-{2-[5-bromo-2-(2,5-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid ethyl ester 
• 25195-56-6 (2,5-difluorobenzyl) methyl sulfone 
• 391934-74-0 tert-Butyl {(2,5-difluorobenzyl)[(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]piperidin-1-yl}phenyl)sulfonyl]amino}acetate 

Relevant articles and documents

Facile bucky-bowl synthesis by regiospecific cove-region closure by Hf elimination

Building bowls: An effective intramolecular aryl-aryl coupling is the key step in rational fullerene synthesis and in synthesis of extended buckybowl structures. Such a process can be embodied very efficiently through quantitative HF elimination on active Al2O3. The process is characterized by an unprecedentedly high chemoselectivity and regiospecificity. Copyright

Scavenger assisted combinatorial process for preparing libraries of tertiary amine compounds

This invention relates to a novel solution phase process for the preparation of tertiary amine combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.

9-(2-fluorobenzyl)-6-(alkylamino)-9H-purines. A new class of anticonvulsant agents

Several substituted aryl and 6-alkylamino analogues of the anticonvulsant purine 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Derivatives with a second fluoro substituent in the 5- or 6-position of the aryl moiety were very active with ip ED50's that ranged from 2 to 4 mg/kg. Congeners in which the purine 6-substituent was varied among a number of alkylamino groups possessed potent activity against MES that was comparable to or several times better than phenytoin.