3-(2-Propynyloxy)propanoic acid

Base Information

• Chemical Name: 3-(2-Propynyloxy)propanoic acid
• CAS No.: 55683-37-9
• Molecular Formula: C6H8O3
• Molecular Weight: 128.128
• Mol file: 55683-37-9.mol

Synonyms:

Chemical Property of 3-(2-Propynyloxy)propanoic acid

Chemical Property:

• Vapor Pressure: 0.00259mmHg at 25°C
• Boiling Point: 265.8°C at 760 mmHg
• PKA: 4.19±0.10(Predicted)
• Flash Point: 113.9°C
• PSA: 46.53000
• Density: 1.14g/cm³
• LogP: 0.11090
• Storage Temp.: -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Prop-2-ynyloxy)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Propargyl-PEG1-acid is a crosslinker with a propargyl group and a carboxylic acid group. The carboxylic acid reacts with primary amine under the activation of HATU or EDC. The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reactions.
• Uses: This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains a single PEG unit to help improve solubility.

Technology Process of 3-(2-Propynyloxy)propanoic acid

There total 1 articles about 3-(2-Propynyloxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl 3-(prop-2-yn-1-yloxy)propanoate (488150-84-1) → 3-(prop-2-yn-1-yloxy)propanoic acid (55683-37-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield: 89.0%

tert-butyl 1-((4-(4-(3-aminopropoxy)benzoyl)phenyl)amino)-3,6,9,12-tetraoxapentadecan-15-oate + 3-(prop-2-yn-1-yloxy)propanoic acid (55683-37-9) → tert-butyl 1-((4-(4-(3-(3-(prop-2-yn-1-yloxy)propanamido)propoxy)benzoyl)phenyl)amino)-3,6,9,12-tetraoxapentadecan-15-oate

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 35.0%

(3S,7S,10R,16S,E)-16-((S)-1-((2R,3R)-3-(4-(azidomethyl)phenyl)oxiran-2-yl)ethyl)-10-(3-chloro-4-methoxybenzyl)-6,6,7-trimethyl-3-neopentyl-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone + 3-(prop-2-yn-1-yloxy)propanoic acid (55683-37-9) → 3-((1-(4-((2R,3R)-3-((S)-1-((3S,7S,10R,16S,E)-10-(3-chloro-4-methoxybenzyl)-6,6,7-trimethyl-3-neopentyl-2,5,9,12-tetraoxo-1-oxa-4,8,11-triazacyclohexadec-13-en-16-yl)ethyl)oxiran-2-yl)benzyl)-1H-1,2,3-triazol-4-yl)methoxy)propanoic acid

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; water; at 20 ℃; for 24h;

upstream raw materials:

tert-butyl 3-(prop-2-yn-1-yloxy)propanoate

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