1-Piperazinecarboxylic acid, 4-[3,5-bis(trifluoromethyl)benzoyl]-3-(1H-indol-3-ylmethyl)-, 1,1-dimethylethyl ester, (3R)-

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[3,5-bis(trifluoromethyl)benzoyl]-3-(1H-indol-3-ylmethyl)-, 1,1-dimethylethyl ester, (3R)-
CAS No.:393102-25-5
Molecular Formula:C27H27F6N3O3
Molecular Weight:555.52
Hs Code.:
Mol file:393102-25-5.mol

Synonyms:

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[3,5-bis(trifluoromethyl)benzoyl]-3-(1H-indol-3-ylmethyl)-, 1,1-dimethylethyl ester, (3R)-

Chemical Property:

Purity/Quality:

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Technology Process of 1-Piperazinecarboxylic acid, 4-[3,5-bis(trifluoromethyl)benzoyl]-3-(1H-indol-3-ylmethyl)-, 1,1-dimethylethyl ester, (3R)-

There total 1 articles about 1-Piperazinecarboxylic acid, 4-[3,5-bis(trifluoromethyl)benzoyl]-3-(1H-indol-3-ylmethyl)-, 1,1-dimethylethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 169458-93-9
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(1H-indol-3-yl)methyl]piperazine

aqueous tartaric acid: aqueous tartaric acid

: 762-75-4
tert-butyl formate

: 393102-25-5
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-ylmethyl]-4-(tert-butoxycarbonyl)piperazine

Guidance literature:: With potassium carbonate; In tetrahydrofuran; ligroin; water;

Reference yield:

: 393102-25-5
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-ylmethyl]-4-(tert-butoxycarbonyl)piperazine

: 74-88-4
methyl iodide

: (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1-methyl-indol-3-ylmethyl)-4-(tert-butoxycarbonyl)piperazine

Guidance literature:: (2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-ylmethyl]-4-(tert-butoxycarbonyl)piperazine; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.166667h;

methyl iodide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 4h;

Reference yield:

: 393102-25-5
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1H-indol-3-ylmethyl]-4-(tert-butoxycarbonyl)piperazine

: 169458-95-1
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(1-methyl-indol-3-ylmethyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.17 h / 20 °C

1.2: 4 h / 20 °C

2.1: hydrogenchloride / methanol; water / 48 h / 20 °C

With hydrogenchloride; sodium hydride; In methanol; DMF (N,N-dimethyl-formamide); water;