8-Methoxy-2-phenylquinoline

Base Information

• Chemical Name: 8-Methoxy-2-phenylquinoline
• CAS No.: 393109-89-2
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID00573769
• Nikkaji Number: J1.601.882A
• Wikidata: Q82462590
• Mol file: 393109-89-2.mol

Synonyms:8-Methoxy-2-phenylquinoline;393109-89-2;SCHEMBL8889339;DTXSID00573769;HMS3409E08;SB71135

Chemical Property of 8-Methoxy-2-phenylquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 3.91040
• Storage Temp.: 2-8°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 235.099714038
• Heavy Atom Count: 18
• Complexity: 262

Purity/Quality:

98.5% ^*data from raw suppliers

8-Methoxy-2-phenylquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1N=C(C=C2)C3=CC=CC=C3

Technology Process of 8-Methoxy-2-phenylquinoline

There total 14 articles about 8-Methoxy-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(2-methoxyphenyl)-2-phenyl-4-trimethylsilyl-1-azabut-1-en-3-yne → 8-methoxy-2-phenylquinoline (393109-89-2)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; ammonium hexafluorophosphate; chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); In toluene; at 105 ℃; for 19h;

DOI:10.1021/ja060626a

Reference yield: 88.0%

8-methoxyquinoline (938-33-0) + diphenylzinc (1078-58-6) → 8-methoxy-2-phenylquinoline (393109-89-2)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; tricyclohexylphosphine; In toluene; at 160 ℃; for 20h; Inert atmosphere;

DOI:10.1002/asia.201100971

Reference yield: 81.0%

2,3-diphenyl-2,3-butanediol (1636-34-6) + 3-methoxy 2-nitrobenzaldehyde (53055-05-3) → 8-methoxy-2-phenylquinoline (393109-89-2)

Guidance literature:

With [MoO₂Cl₂(dmf)₂]; In N,N-dimethyl acetamide; at 180 ℃; for 1h; regioselective reaction; Sealed tube; Microwave irradiation;

DOI:10.1002/adsc.201800278

upstream raw materials:

8-methoxyquinoline

phenyllithium

Isatophan

2-amino-3-methoxy-benzaldehyde

Downstream raw materials:

6-phenyl-2-hydroxypyridine-3-carboxylic acid