2-Amino-3-methoxybenzaldehyde

Base Information

• Chemical Name: 2-Amino-3-methoxybenzaldehyde
• CAS No.: 70127-96-7
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.165
• Hs Code.: 2922500090
• DSSTox Substance ID: DTXSID10553471
• Nikkaji Number: J2.552.162E
• Wikidata: Q82434060
• Mol file: 70127-96-7.mol

Synonyms:2-Amino-3-methoxybenzaldehyde;70127-96-7;3-methoxy-2-aminobenzaldehyde;2-AMINO-3-METHOXY-BENZALDEHYDE;BENZALDEHYDE, 2-AMINO-3-METHOXY-;2amino-3-methoxy-benzaldehyde;3-methoxy-2-aminobenz-aldehyde;SCHEMBL1043732;DTXSID10553471;GDIYDPBHVKDDIR-UHFFFAOYSA-N;MFCD09999245;AKOS006302167;AB55845;DS-0388;2-Amino-3-methoxybenzaldehyde, AldrichCPR;Benzaldehyde, 2-amino-3-methoxy- (9CI);A866672;J-507794

Chemical Property of 2-Amino-3-methoxybenzaldehyde

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-3-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1N)C=O

Technology Process of 2-Amino-3-methoxybenzaldehyde

There total 6 articles about 2-Amino-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methoxy 2-nitrobenzaldehyde (53055-05-3) → 2-amino-3-methoxy-benzaldehyde (70127-96-7)

Guidance literature:

With iron; In ethanol; water; for 4h; Reflux;

DOI:10.1021/acs.inorgchem.8b01438

Reference yield: 74.0%

(2-amino-3-methoxyphenyl)methanol (205877-13-0) → 2-amino-3-methoxy-benzaldehyde (70127-96-7)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 23h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.08.004

Reference yield: 61.0%

3-methoxy 2-nitrobenzaldehyde (53055-05-3) → 2-amino-3-methoxy-benzaldehyde (70127-96-7) + 7-methoxy-2,1-benzisoxazole (122528-40-9)

Guidance literature:

With 2-bromo-2-nitropropane; indium; In methanol; water; at 50 ℃; for 0.166667h;

DOI:10.1016/S0040-4039(00)00098-8

upstream raw materials:

3-methoxy 2-nitrobenzaldehyde

(2-amino-3-methoxyphenyl)methanol

2-amino-3-methoxybenzoic acid

Downstream raw materials:

8-methoxy-3-phenyl-quinolin-2-ylamine

8-methoxyquinoline-2-carboxylic acid

8-methoxyquinoline-3-carbonitrile

tert-butyl 4-((2-chloroquinazolin-8-yl)oxy)piperidine-1-carboxylate