1-Pyrrolidinecarboxylic acid, 4-mercapto-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 4-mercapto-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)-
CAS No.:393789-23-6
Molecular Formula:C21H20F3NO5S
Molecular Weight:455.455
Hs Code.:
Mol file:393789-23-6.mol

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 4-mercapto-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 4-mercapto-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 4-mercapto-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)-

There total 6 articles about 1-Pyrrolidinecarboxylic acid, 4-mercapto-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 393792-62-6
(2S,4R)-2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidine-1-carboxylic acid 2-methoxycarbonylphenyl ester

: 393789-23-6
(2S,4R)-4-mercapto-2-(2,4,5-trifluorobenzyloxymethyl)pyrrolidine-1-carboxylic acid 2-methoxycarbonylphenyl ester

Guidance literature:: With triethylsilane; trifluoroacetic acid; at 20 ℃; for 0.25h;
DOI:10.1021/jm040857x

Reference yield:

: 337307-10-5
(2S,4R)-2-Hydroxymethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 393789-23-6
(2S,4R)-4-mercapto-2-(2,4,5-trifluorobenzyloxymethyl)pyrrolidine-1-carboxylic acid 2-methoxycarbonylphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 70 percent / NaH / dimethylformamide / 0 - 20 °C

2.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 5.5 h / -20 - 20 °C

3.1: quinoline / CH₂Cl₂ / 2 h / 0 °C

3.2: 95 percent / NaH; KI / tetrahydrofuran / 3 h / Heating

4.1: 85 percent / trifluoroacetic acid; Et₃SiH / 0.25 h / 20 °C

With quinoline; triethylsilane; sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040857x

Reference yield:

: 176306-17-5
(2S,4R)-4-tritylsulfanylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl-2-methyl diester

: 393789-23-6
(2S,4R)-4-mercapto-2-(2,4,5-trifluorobenzyloxymethyl)pyrrolidine-1-carboxylic acid 2-methoxycarbonylphenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / -20 °C

2.1: 70 percent / NaH / dimethylformamide / 0 - 20 °C

3.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 5.5 h / -20 - 20 °C

4.1: quinoline / CH₂Cl₂ / 2 h / 0 °C

4.2: 95 percent / NaH; KI / tetrahydrofuran / 3 h / Heating

5.1: 85 percent / trifluoroacetic acid; Et₃SiH / 0.25 h / 20 °C

With quinoline; triethylsilane; lithium aluminium tetrahydride; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040857x