1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)-
CAS No.:393792-62-6
Molecular Formula:C40H34F3NO5S
Molecular Weight:697.775
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-,
2-(methoxycarbonyl)phenyl ester, (2S,4R)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)-

Chemical Property:

Purity/Quality:

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)-

There total 6 articles about 1-Pyrrolidinecarboxylic acid, 2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphenylmethyl)thio]-, 2-(methoxycarbonyl)phenyl ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 503-38-8
trichloromethyl chloroformate

: 119-36-8,8024-54-2
methyl salicylate

: 391888-89-4
(2S,4R)-2-(2,4,5-Trifluoro-benzyloxymethyl)-4-tritylsulfanyl-pyrrolidine

: 393792-62-6
(2S,4R)-2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidine-1-carboxylic acid 2-methoxycarbonylphenyl ester

Guidance literature:: trichloromethyl chloroformate; (2S,4R)-2-(2,4,5-Trifluoro-benzyloxymethyl)-4-tritylsulfanyl-pyrrolidine; With quinoline; In dichloromethane; at 0 ℃; for 2h;

methyl salicylate; With sodium hydride; potassium iodide; In tetrahydrofuran; for 3h; Heating;
DOI:10.1021/jm040857x

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 393792-62-6
(2S,4R)-2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidine-1-carboxylic acid 2-methoxycarbonylphenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / CCl₄; PPh₃ / CH₂Cl₂ / 4 h / 3 - 35 °C

2.1: KO-t-Bu / dimethylformamide / 0.33 h / 20 °C

2.2: 83 percent / dimethylformamide / 3.25 h / 0 - 20 °C

3.1: 100 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / -20 °C

4.1: 70 percent / NaH / dimethylformamide / 0 - 20 °C

5.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 5.5 h / -20 - 20 °C

6.1: quinoline / CH₂Cl₂ / 2 h / 0 °C

6.2: 95 percent / NaH; KI / tetrahydrofuran / 3 h / Heating

With quinoline; tetrachloromethane; lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040857x

Reference yield:

: 337307-10-5
(2S,4R)-2-Hydroxymethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 393792-62-6
(2S,4R)-2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidine-1-carboxylic acid 2-methoxycarbonylphenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 70 percent / NaH / dimethylformamide / 0 - 20 °C

2.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 5.5 h / -20 - 20 °C

3.1: quinoline / CH₂Cl₂ / 2 h / 0 °C

3.2: 95 percent / NaH; KI / tetrahydrofuran / 3 h / Heating

With quinoline; sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040857x