16,17-pyrazoleestrone

Base Information

Chemical Name:16,17-pyrazoleestrone
CAS No.:3460-91-1
Molecular Formula:C₁₉H₂₂N₂O
Molecular Weight:294.396
Hs Code.:
Mol file:3460-91-1.mol

Synonyms:Naphth[2',1':4,5]indeno[1,2-c]pyrazol-2-ol,4b,5,6,6a,8,10,10a,10b,11,12-decahydro-6a-methyl- (7CI); 16,17-PES; 16,17-Pyrazoleestrone;3-Hydroxyestra-1,3,5(10)-trieno-[17,16-c]pyrazole

Suppliers and Price of 16,17-pyrazoleestrone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 16,17-pyrazoleestrone

Chemical Property:

Boiling Point:520.3°Cat760mmHg
Flash Point:268.4°C
PSA：48.91000
Density:1.242g/cm³
LogP:3.68530

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 16,17-pyrazoleestrone

There total 5 articles about 16,17-pyrazoleestrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 882045-26-3
16-hydroxymethylene-estrone

: 20799-49-9,3460-91-1
3-hydroxyestra-1,3,5(10)-triene-[17,16-c]-pyrazole

Guidance literature:: With hydrazine hydrate; In ethanol; for 0.5h; Heating;
DOI:10.1021/jm050348a

Reference yield:

: 882045-25-2
3-O-tert-butyldimethylsilyl-16-hydroxymethyleneestrone

: 20799-49-9,3460-91-1
3-hydroxyestra-1,3,5(10)-triene-[17,16-c]-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: TBAF / tetrahydrofuran / 20 °C

2: 64 percent / hydrazine hydrate / ethanol / 0.5 h / Heating

With tetrabutyl ammonium fluoride; hydrazine hydrate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm050348a

Reference yield:

: 53-16-7
Estrone

: 20799-49-9,3460-91-1
3-hydroxyestra-1,3,5(10)-triene-[17,16-c]-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: imidazole / dimethylformamide

2.1: NaOMe / toluene / 0.33 h / 20 °C

2.2: 98 percent / toluene

3.1: TBAF / tetrahydrofuran / 20 °C

4.1: 64 percent / hydrazine hydrate / ethanol / 0.5 h / Heating

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium methylate; hydrazine hydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm050348a