(5-(THIOPHEN-2-YL)PYRIDIN-3-YL)METHANOL

Base Information

• Chemical Name: (5-(THIOPHEN-2-YL)PYRIDIN-3-YL)METHANOL
• CAS No.: 393861-00-2
• Molecular Formula: C10H9NOS
• Molecular Weight: 191.25000
• Hs Code.: 2934999090
• Mol file: 393861-00-2.mol

Synonyms:3-(hydroxymethyl)-5-(2-thiophene)pyridine;3-(hydroxymethyl)-2-nonanone;2-Nonanone,3-(hydroxymethyl);

Chemical Property of (5-(THIOPHEN-2-YL)PYRIDIN-3-YL)METHANOL

Chemical Property:

• PSA: 61.36000
• LogP: 2.30240
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,5-bis(ethylamino)nicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-(THIOPHEN-2-YL)PYRIDIN-3-YL)METHANOL

There total 2 articles about (5-(THIOPHEN-2-YL)PYRIDIN-3-YL)METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

thiophene boronic acid (6165-68-0) + (5-bromopyridin-3-yl)methanol (37669-64-0) → 3-(hydroxymethyl)-5-(2-thiophene)pyridine (393861-00-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; toluene; at 70 ℃; for 20h;

DOI:10.1021/jm010246u

Reference yield:

5-bromo-3-pyridinecarboxylic acid (20826-04-4) → 3-(hydroxymethyl)-5-(2-thiophene)pyridine (393861-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 29 percent / BH₃*THF / tetrahydrofuran / 4 h / Heating

2: 65 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol / 20 h / 70 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sodium carbonate; In tetrahydrofuran; methanol; toluene; 2: Suzuki coupling reaction;

DOI:10.1021/jm010246u

upstream raw materials:

thiophene boronic acid

(5-bromopyridin-3-yl)methanol

5-bromo-3-pyridinecarboxylic acid