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5-Bromonicotinic acid TOP1 supplier
Cas No: 20826-04-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
5-bromopyridine-3-carboxylate
Cas No: 20826-04-4
No Data 1 Kilogram 1 Metric Ton/Month HANGZHOU YUNUO CHEMICAL CO.,LTD Contact Supplier
High purity 5-Bromonicotinic acid with high quality and best price cas:20826-04-4
Cas No: 20826-04-4
USD $ 45.0-60.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality 5-Bromonicotinic Acid supplier in China
Cas No: 20826-04-4
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5-Bromonicotinic acid
Cas No: 20826-04-4
USD $ 12.0-12.0 / Gram 100 Gram 50 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
5-Bromonicotinic acid
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No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Large Stock 99.0% 5-Bromonicotinic acid 20826-04-4 Producer
Cas No: 20826-04-4
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply 5-bromonicotinic acid
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5-Bromonicotinic acid CAS: 20826-04-4
Cas No: 20826-04-4
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
CHemwill -- 5-Bromonicotinic acid
Cas No: 20826-04-4
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier

20826-04-4 Usage

Chemical Properties

Light yellow Cryst

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 2381, 1948 DOI: 10.1021/ja01187a020

Purification Methods

The acid is recrystallised from H2O and then from EtOH using charcoal. The amide has m 219-219.5o (from aqueous EtOH), and the methyl ester, prepared by addition of ethereal diazomethane, can be purified by sublimation in a vacuum and has m 98-99o. The acid chloride also can be sublimed in vacuo and has m 74-75o and gives the methyl ester in MeOH. [Graf J Prakt Chem 138 244 1933, Bachman & Micucci J Am Chem Soc 70 2381 1948, Garcia et al. J Am Chem Soc 82 4430 1960, Misic-Vokovic et al. J Chem Soc 34 1978, Beilstein 22/2 V 181.]
InChI:InChI=1/C6H4BrNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,(H,9,10)/p-1

20826-04-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A13589)  5-Bromonicotinic acid, 98%    20826-04-4 5g 362.0CNY Detail
Alfa Aesar (A13589)  5-Bromonicotinic acid, 98%    20826-04-4 25g 1064.0CNY Detail
Alfa Aesar (A13589)  5-Bromonicotinic acid, 98%    20826-04-4 100g 3983.0CNY Detail
Sigma-Aldrich (Y0001356)  NicergolineimpurityD  European Pharmacopoeia (EP) Reference Standard 20826-04-4 Y0001356 1,880.19CNY Detail
Aldrich (228435)  5-Bromopyridine-3-carboxylicacid  98% 20826-04-4 228435-10G 477.01CNY Detail
Aldrich (228435)  5-Bromopyridine-3-carboxylicacid  98% 20826-04-4 228435-50G 2,359.89CNY Detail

20826-04-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromopyridine-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 3-Pyridinecarboxylic acid,5-bromo

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20826-04-4 SDS

20826-04-4Synthetic route

5-bromonicotinamide
28733-43-9

5-bromonicotinamide

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With acetic acid; isopentyl nitrite at 80℃; for 24h; Inert atmosphere;98%
3-pyridinecarbonyl chloride
10400-19-8

3-pyridinecarbonyl chloride

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With bromine at 0 - 155℃; for 10h;94%
5-bromo-3-pyridine carboxylic acid methyl ester
29681-44-5

5-bromo-3-pyridine carboxylic acid methyl ester

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With potassium hydroxide In methanol; water for 12h; Ambient temperature;91%
With water; sodium hydroxide In tetrahydrofuran at 20℃; for 0.166667h;33%

A

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

B

1-Methyl-10alpha-methoxy-9,10-dihydrolysergol
35155-28-3

1-Methyl-10alpha-methoxy-9,10-dihydrolysergol

Conditions
ConditionsYield
With potassium hydroxide In methanol Heating;A 12%
B 91%
3,5-dibromopyridine
625-92-3

3,5-dibromopyridine

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With n-butyllithium; diethyl ether at -30℃; Behandeln der Reaktionsloesung mit festem CO2;
nicotinic acid
59-67-6

nicotinic acid

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With thionyl chloride Erhitzen des Reaktionsprodukts mit Brom auf 150-170grad und Behandeln des Reaktionsgemisches mit H2O bei pH 3;
3-bromoquinoline
5332-24-1

3-bromoquinoline

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With nitric acid at 150℃;
5-Bromo-pyridine-2,3-dicarboxylic acid
98555-51-2

5-Bromo-pyridine-2,3-dicarboxylic acid

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With acetic acid
beim Schmelzen;
para-bromophenacyl bromide
99-73-0

para-bromophenacyl bromide

<5-3H>-sesbanine

<5-3H>-sesbanine

A

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

B

<5-3H>-nicotinic acid
109440-03-1

<5-3H>-nicotinic acid

C

5-Bromo-nicotinic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester

5-Bromo-nicotinic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester

Conditions
ConditionsYield
With pyridine; potassium hydroxide; potassium permanganate; thionyl chloride; bromine; benzoyl chloride multistepreaction to study the origin of the carbon skeleton;
3.bz.bz-tribromo-6-methoxy-quinoline

3.bz.bz-tribromo-6-methoxy-quinoline

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With nitric acid
5-bromo-quinolinic acid

5-bromo-quinolinic acid

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

diazotized 5-amino-nicotinic acid

diazotized 5-amino-nicotinic acid

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With copper(I) bromide
5-bromo-3-picoline
3430-16-8

5-bromo-3-picoline

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
ConditionsYield
With potassium permanganate Heating;
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate
144222-22-0

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

tert-butyl 4-((5-bromonicotinamido)methyl)piperidine-1-carboxylate

tert-butyl 4-((5-bromonicotinamido)methyl)piperidine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 80℃; for 2h; Microwave irradiation;100%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

tert-butyl-4-(5-bromonicotinoyl)piperazine-1-carboxylate

tert-butyl-4-(5-bromonicotinoyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 80℃; for 2h; Microwave irradiation;100%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

ethanol
64-17-5

ethanol

ethyl 5-bromo-3-pyridinecarboxylate
20986-40-7

ethyl 5-bromo-3-pyridinecarboxylate

Conditions
ConditionsYield
Stage #1: 5-bromo-3-pyridinecarboxylic acid With thionyl chloride Reflux;
Stage #2: ethanol for 2h; Reflux;
Stage #3: With sodium hydrogencarbonate In dichloromethane; water pH=8;
99%
With sulfuric acid for 18h; Heating;94%
With sulfuric acid for 18h; Inert atmosphere; Reflux; Cooling with ice;89%
5-((1S,2S)-2-Hydroxy-1-methyl-5-oxo-cyclopentyl)-pentanoic acid methyl ester
915285-91-5

5-((1S,2S)-2-Hydroxy-1-methyl-5-oxo-cyclopentyl)-pentanoic acid methyl ester

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

5-Bromo-nicotinic acid (1S,2S)-2-(4-methoxycarbonyl-butyl)-2-methyl-3-oxo-cyclopentyl ester

5-Bromo-nicotinic acid (1S,2S)-2-(4-methoxycarbonyl-butyl)-2-methyl-3-oxo-cyclopentyl ester

Conditions
ConditionsYield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 20h;99%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

3-methyl-4-isopropylaniline hydrochloride
4534-11-6

3-methyl-4-isopropylaniline hydrochloride

5-bromo-N-(4-isopropyl-3-methylphenyl)pyridine-3-carboxamide

5-bromo-N-(4-isopropyl-3-methylphenyl)pyridine-3-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;98.2%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

5-bromo-3-pyridine carboxylic acid methyl ester
29681-44-5

5-bromo-3-pyridine carboxylic acid methyl ester

Conditions
ConditionsYield
In tetrahydrofuran; diethyl ether for 2h; Ambient temperature;97%
In diethyl ether for 0.25h;
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

1-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5,6,7,8-tetrahydro-isoquinoline
872175-75-2

1-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5,6,7,8-tetrahydro-isoquinoline

5-(1-methoxy-5,6,7,8-tetrahydro-isoquinolin-4-yl)-nicotinic acid
872175-89-8

5-(1-methoxy-5,6,7,8-tetrahydro-isoquinolin-4-yl)-nicotinic acid

Conditions
ConditionsYield
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In DMF (N,N-dimethyl-formamide) at 110℃; for 18h; Suzuki Coupling;97%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

(S)-tert-butyl(dimethyl)[3-(S-phenylsulfonimidoyl)propoxy]silane

(S)-tert-butyl(dimethyl)[3-(S-phenylsulfonimidoyl)propoxy]silane

(S)-5-bromo-N-[(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)(oxido)phenyl-λ4-sulfanylidene]nicotinamide

(S)-5-bromo-N-[(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)(oxido)phenyl-λ4-sulfanylidene]nicotinamide

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.25h;97%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

pivaloyl chloride
3282-30-2

pivaloyl chloride

tert-butylcarbonyl-5-bromonicotinic acid
133343-68-7

tert-butylcarbonyl-5-bromonicotinic acid

Conditions
ConditionsYield
With triethylamine In benzene for 16h; Ambient temperature; 1.) C6H6, RT, 1 h, 2.) C6H6, 16 h;96%
With triethylamine In benzene95%
Stage #1: 5-bromo-3-pyridinecarboxylic acid With triethylamine In toluene at 0 - 20℃; for 1h; Inert atmosphere; Schlenk technique;
Stage #2: pivaloyl chloride In toluene at 0 - 20℃; Inert atmosphere; Schlenk technique;
77%
methanol
67-56-1

methanol

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

5-bromo-3-pyridine carboxylic acid methyl ester
29681-44-5

5-bromo-3-pyridine carboxylic acid methyl ester

Conditions
ConditionsYield
Stage #1: 5-bromo-3-pyridinecarboxylic acid With boron trichloride
Stage #2: methanol
96%
sulfuric acid for 3h; Heating / reflux;90%
With sulfuric acid at 65℃;88%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

C20H19NO4

C20H19NO4

(S)-1-[5-(4-Fluoro-phenyl)-pyridine-3-carbonyl]-pyrrolidine-2-carboxylic acid

(S)-1-[5-(4-Fluoro-phenyl)-pyridine-3-carbonyl]-pyrrolidine-2-carboxylic acid

Conditions
ConditionsYield
Multistep reaction;96%
4-((1S,2S)-2-Hydroxy-1-methyl-5-oxo-cyclopentyl)-butyric acid methyl ester
915285-93-7

4-((1S,2S)-2-Hydroxy-1-methyl-5-oxo-cyclopentyl)-butyric acid methyl ester

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

5-Bromo-nicotinic acid (1S,2S)-2-(3-methoxycarbonyl-propyl)-2-methyl-3-oxo-cyclopentyl ester

5-Bromo-nicotinic acid (1S,2S)-2-(3-methoxycarbonyl-propyl)-2-methyl-3-oxo-cyclopentyl ester

Conditions
ConditionsYield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 20h;96%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 5-bromopyridine-3-carboxylate
263270-02-6

tert-butyl 5-bromopyridine-3-carboxylate

Conditions
ConditionsYield
With dmap In tetrahydrofuran Reflux;96%
With 4-pyrrolidin-1-ylpyridine; triethylamine In tetrahydrofuran at 20℃; for 48h;91%
With dmap In tetrahydrofuran at 20℃; for 1.5h; Cooling with ice;82%
With dmap In tetrahydrofuran for 1h; Reflux;79%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

3-iodo-4-methylaniline
35944-64-0

3-iodo-4-methylaniline

C13H10BrIN2O

C13H10BrIN2O

Conditions
ConditionsYield
Stage #1: 5-bromo-3-pyridinecarboxylic acid With thionyl chloride In toluene at 82℃; for 2h;
Stage #2: 3-iodo-4-methylaniline With triethylamine In toluene at 20℃;
96%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

5-bromonicotinoyl chloride
39620-02-5

5-bromonicotinoyl chloride

Conditions
ConditionsYield
With thionyl chloride for 12h; Reflux;95%
With thionyl chloride In dichloromethane for 2h; Reflux;64%
With thionyl chloride
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

5-bromonicotinic acid chloride hydrochloride

5-bromonicotinic acid chloride hydrochloride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane Reflux;95%
With thionyl chloride for 4h;92%
With oxalyl dichloride
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide 0 deg C, 1 h; RT, 30 min;
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Tocopherol
59-02-9

Tocopherol

(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl 5-bromonicotinate

(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl 5-bromonicotinate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In tetrahydrofuran Inert atmosphere;95%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

5-bromo-3-pyridine carboxylic acid methyl ester
29681-44-5

5-bromo-3-pyridine carboxylic acid methyl ester

Conditions
ConditionsYield
In methanol94%
Multi-step reaction with 2 steps
1: SOCl2
View Scheme
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

(R)-S-methyl-S-phenylsulfoximine
60933-65-5

(R)-S-methyl-S-phenylsulfoximine

(R)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide
1027725-42-3

(R)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 2.66667h;94%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

[{Mo(O)(5,10,15,20-meso-tetrakis(4-bromophenyl)porphyrin)}2O]

[{Mo(O)(5,10,15,20-meso-tetrakis(4-bromophenyl)porphyrin)}2O]

[Mo(O)(5,10,15,20-meso-tetrakis(4-bromophenyl)porphyrin)(5-bromonicotinate)]

[Mo(O)(5,10,15,20-meso-tetrakis(4-bromophenyl)porphyrin)(5-bromonicotinate)]

Conditions
ConditionsYield
In methanol; chloroform for 0.5h;94%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

5-aminonicotinic acid
24242-19-1

5-aminonicotinic acid

Conditions
ConditionsYield
Stage #1: 5-bromo-3-pyridinecarboxylic acid With copper(ll) sulfate pentahydrate; ammonia In water at 170 - 180℃; for 19h; Autoclave;
Stage #2: In water pH=4 - 5; Acidic aq. solution;
93%
With copper(I) sulfate; ammonia In water at 120℃; for 16h; Acidic aqueous solution;74%
With ammonia; copper(II) sulfate In water at 180℃; for 15h;64%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Fmoc-Leu-OH
35661-60-0

Fmoc-Leu-OH

4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

(S)-2-{[5-(4-Fluoro-phenyl)-pyridine-3-carbonyl]-amino}-4-methyl-pentanoic acid

(S)-2-{[5-(4-Fluoro-phenyl)-pyridine-3-carbonyl]-amino}-4-methyl-pentanoic acid

Conditions
ConditionsYield
Multistep reaction;93%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

N-methyl-N-methoxy-5-bromopyridine-3-carboxamide
183608-47-1

N-methyl-N-methoxy-5-bromopyridine-3-carboxamide

Conditions
ConditionsYield
With oxalyl dichloride; triethylamine In tetrahydrofuran at 0 - 20℃; for 4h;93%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; Inert atmosphere;86%
Stage #1: 5-bromo-3-pyridinecarboxylic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 4h;
Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane at 20℃; for 3.5h;
73%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 1-methyl-pyrrolidin-2-one; dichloromethane at 0 - 20℃;51.1%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In 1-methyl-pyrrolidin-2-one; dichloromethane at 0 - 20℃;51.1%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

phenylboronic acid
98-80-6

phenylboronic acid

5-phenylnicotinic acid
10177-12-5

5-phenylnicotinic acid

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 70℃; for 1.66667h; Suzuki Coupling;93%
With meso-tetrakis[4-(methoxycarbonyl)phenyl]porphyrinatopalladium(II); potassium carbonate In water at 80℃; for 4.66667h; Suzuki Coupling; Green chemistry;91%
With potassium carbonate In water; N,N-dimethyl-formamide at 80℃; for 0.333333h; Catalytic behavior; Suzuki-Miyaura Coupling;82%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

descarboethoxyloratadine
100643-71-8

descarboethoxyloratadine

(5-Bromo-pyridin-3-yl)-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-methanone

(5-Bromo-pyridin-3-yl)-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-methanone

Conditions
ConditionsYield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide for 18h; Ambient temperature;92%
5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

(S)-S-methyl-S-phenylsulfoximine
4381-25-3, 33903-50-3, 60933-65-5, 81162-81-4

(S)-S-methyl-S-phenylsulfoximine

(S)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide
1027729-52-7

(S)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 2.16667h;92%
4-aminopyridine
504-24-5

4-aminopyridine

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

5-bromo-N-(pyridin-4-yl)nicotinamide
634173-90-3

5-bromo-N-(pyridin-4-yl)nicotinamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;92%
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