1,6-Dihydro-2-(2-(2-methylpropoxy)phenyl)-6-oxo-5-pyrimidinecarboxylic acid

Base Information

Chemical Name:1,6-Dihydro-2-(2-(2-methylpropoxy)phenyl)-6-oxo-5-pyrimidinecarboxylic acid
CAS No.:98772-41-9
Molecular Formula:C16H17N3O5
Molecular Weight:331.328
Hs Code.:
DSSTox Substance ID:DTXSID60913086

Synonyms:BRN 5629217;1,6-Dihydro-2-(2-(2-methylpropoxy)phenyl)-6-oxo-5-pyrimidinecarboxylic acid;5-Pyrimidinecarboxylic acid, 1,4-dihydro-4-oxo-2-((2-((tetrahydro-2-furanyl)methoxy)phenyl)amino)-;98772-41-9;DTXSID60913086;LS-134854;4-Hydroxy-2-{2-[(oxolan-2-yl)methoxy]anilino}pyrimidine-5-carboxylic acid

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,6-Dihydro-2-(2-(2-methylpropoxy)phenyl)-6-oxo-5-pyrimidinecarboxylic acid

Chemical Property:

Vapor Pressure:7.06E-12mmHg at 25°C
Boiling Point:525.6°C at 760 mmHg
Flash Point:271.7°C
Density:1.48g/cm³
XLogP3:1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:331.11682065
Heavy Atom Count:24
Complexity:560

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(OC1)COC2=CC=CC=C2NC3=NC=C(C(=O)N3)C(=O)O

Technology Process of 1,6-Dihydro-2-(2-(2-methylpropoxy)phenyl)-6-oxo-5-pyrimidinecarboxylic acid

There total 4 articles about 1,6-Dihydro-2-(2-(2-methylpropoxy)phenyl)-6-oxo-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 98771-67-6
6-Oxo-2-[2-(tetrahydro-furan-2-ylmethoxy)-phenylamino]-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester

: 98772-41-9
6-Oxo-2-[2-(tetrahydro-furan-2-ylmethoxy)-phenylamino]-1,6-dihydro-pyrimidine-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 80 ℃; for 2h;
DOI:10.1248/cpb.37.1780

Reference yield:

: 53554-29-3
ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate

: 98772-41-9
6-Oxo-2-[2-(tetrahydro-furan-2-ylmethoxy)-phenylamino]-1,6-dihydro-pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / ethanol / 15 h / Heating

2: 60 percent / 4percent aq. NaOH / methanol / 2 h / 80 °C

With sodium hydroxide; In methanol; ethanol;
DOI:10.1248/cpb.37.1780

Reference yield:

: 169330-16-9
o-nitrophenyl tetrahydro-2-furfuryl ether

: 98772-41-9
6-Oxo-2-[2-(tetrahydro-furan-2-ylmethoxy)-phenylamino]-1,6-dihydro-pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 10percent Pd/C / methanol

2: 68 percent / ethanol / 15 h / Heating

3: 60 percent / 4percent aq. NaOH / methanol / 2 h / 80 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; ethanol;
DOI:10.1248/cpb.37.1780