Carbamic acid, [[trans-4-[[[(1S)-2-[(4-butylphenyl)amino]-2-oxo-1-[[4-(4-pyridinylmethoxy )phenyl]methyl]ethyl]amino]carbonyl]cyclohexyl]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [[trans-4-[[[(1S)-2-[(4-butylphenyl)amino]-2-oxo-1-[[4-(4-pyridinylmethoxy )phenyl]methyl]ethyl]amino]carbonyl]cyclohexyl]methyl]-, 1,1-dimethylethyl ester
CAS No.:395062-97-2
Molecular Formula:C38H50N4O5
Molecular Weight:642.839
Hs Code.:

Carbamic acid,
[[trans-4-[[[(1S)-2-[(4-butylphenyl)amino]-2-oxo-1-[[4-(4-pyridinylmethoxy
)phenyl]methyl]ethyl]amino]carbonyl]cyclohexyl]methyl]-,
1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [[trans-4-[[[(1S)-2-[(4-butylphenyl)amino]-2-oxo-1-[[4-(4-pyridinylmethoxy )phenyl]methyl]ethyl]amino]carbonyl]cyclohexyl]methyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [[trans-4-[[[(1S)-2-[(4-butylphenyl)amino]-2-oxo-1-[[4-(4-pyridinylmethoxy )phenyl]methyl]ethyl]amino]carbonyl]cyclohexyl]methyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, [[trans-4-[[[(1S)-2-[(4-butylphenyl)amino]-2-oxo-1-[[4-(4-pyridinylmethoxy )phenyl]methyl]ethyl]amino]carbonyl]cyclohexyl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.1%

: 27687-14-5
trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

: 2-amino-N-(4-butyl-phenyl)-3-[4-(pyridin-4-ylmethoxy)-phenyl]-propionamide

: 395062-97-2
(4-{1-(4-butyl-phenylcarbamoyl)-2-[4-(pyridin-4-ylmethoxy)-phenyl]-ethylcarbamoyl}-cyclohexylmethyl)-carbamic acid tert-butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1248/cpb.49.1457

Reference yield:

: 104-13-2
4-Butylaniline

: 395062-97-2
(4-{1-(4-butyl-phenylcarbamoyl)-2-[4-(pyridin-4-ylmethoxy)-phenyl]-ethylcarbamoyl}-cyclohexylmethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N; BOP / dimethylformamide / 15 h / 20 °C

2: TFA; anisole

3: 61.1 percent / Et₃N; BOP / dimethylformamide / 15 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; methoxybenzene; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1457

Reference yield:

: Boc-Tyr(O-Pic)-OH

: 395062-97-2
(4-{1-(4-butyl-phenylcarbamoyl)-2-[4-(pyridin-4-ylmethoxy)-phenyl]-ethylcarbamoyl}-cyclohexylmethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N; BOP / dimethylformamide / 15 h / 20 °C

2: TFA; anisole

3: 61.1 percent / Et₃N; BOP / dimethylformamide / 15 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; methoxybenzene; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1457