4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid

Base Information

• Chemical Name: 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid
• CAS No.: 27687-14-5
• Molecular Formula: C13H23NO4
• Molecular Weight: 257.33
• Hs Code.: 2924299090
• European Community (EC) Number: 830-276-5
• DSSTox Substance ID: DTXSID601347564
• Nikkaji Number: J3.151.644G,J3.151.645E
• Mol file: 27687-14-5.mol

Synonyms:162046-58-4;27687-14-5;BOC-TRANEXAMIC ACID;4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid;Boc-4-Amc-OH;847416-70-0;trans-4-(tert-Butoxycarbonylaminomethyl)cyclohexanecarboxylic Acid;4-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]cyclohexane-1-carboxylic Acid;trans-4-N-Boc-Aminomethyl-cyclohexanecarboxylic acid;trans-4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid;4-(tert-Butoxycarbonylaminomethyl)cyclohexanecarboxylic Acid;MFCD00673773;4-({[(tert-butoxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid;Boc-trans-4-(aminomethyl)-cyclohexane-1-carboxylic acid;cis-(1,1-Dimethylethoxy)carbonyl Tranexamic Acid;cis-4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid;Cis-(4-BOC-Aminomethyl)-cyclohexyl carboxylic acid;4-(([(TERT-BUTOXY)CARBONYL]AMINO)METHYL)CYCLOHEXANE-1-CARBOXYLIC ACID;MFCD01862289;trans-4-[(Boc-amino)methyl]cyclohexanecarboxylic Acid;trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexanecarboxylic acid;4-[(Boc-amino)methyl]cyclohexanecarboxylic Acid;Boc-trans-4-(aminomethyl)cyclohexanecarboxylic acid;cis,trans-(1,1-Dimethylethoxy)carbonylTranexamicAcid-13C2,15N;4-(([(tert-Butoxy)carbonyl]amino)methyl)-cyclohexane-1-carboxylic acid;(1r,4r)-4-({[(tert-butoxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid;4-((BOC-amino)methyl)cyclohexanecarboxylic acid;trans-Boc-tranexamic acid;4-[[(tert-butoxycarbonyl)amino]methyl]cyclohexanecarboxylic acid;cis-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexanecarboxylic acid;4-(Boc-aminomethyl)cyclohexanecarboxylic Acid;cyclohexanecarboxylic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, trans-;Oprea1_175352;Oprea1_341039;trans-4-(Boc-aminomethyl)cyclohexanecarboxylic Acid;SCHEMBL353639;SCHEMBL353652;SCHEMBL5006161;SCHEMBL9885051;SCHEMBL9885629;AZEKNJGFCSHZID-AOOOYVTPSA-N;AZEKNJGFCSHZID-MGCOHNPYSA-N;AZEKNJGFCSHZID-UHFFFAOYSA-N;DTXSID601347564;CBA68714;CS-M2057;BBL028866;STK716513;trans-4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid;(1r,4r)-4-(((tert-butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid;AKOS001064296;AKOS005175122;AKOS032957128;AB86500;BS-4733;AC-29648;AS-37069;SY042490;SY056643;B3251;B3253;CS-0127783;CS-0127908;FT-0667444;FT-0679721;FT-0752291;EN300-99589;D85968;EN300-157668;F31156;A848421;A883020;A934958;A1-50247;N-Boc-trans-4-(aminomethyl)cyclohexanecarboxylic acid;Z56887262;4-((tert-butoxycarbonylamino)methyl)cyclohexanecarboxylic acid;4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid;trans-4-(t-butoxycarbonyl)aminomethylcyclohexylcarboxylic acid;Trans-4-(t-butoxycarbonylamino-methyl)cyclohexanecarboxylic acid;Trans-4-(t-butoxycarbonylaminomethyl)cyclohexanecarboxylic acid;trans-4-(t-butoxycarbonylaminomethyl)cyclohexyl carboxylic acid;trans-4-(t-butoxycarbonylaminomethyl)cyclohexylcarboxylic acid;trans-4-(t-butyloxycarbonyl)aminomethylcyclohexylcarboxylic acid;trans-4-[(tert-Butoxyformamido)methyl]cyclohexanecarboxylic acid;4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid;4-[[(tert-butoxycarbonyl)-amino]methyl] cyclohexanecarboxylic acid;4-[[(tert-butoxycarbonyl)-amino]methyl]-cyclohexanecarboxylic acid;4-[[(tert-butoxycarbonyl)-amino]methyl]cyclohexanecarboxylic acid;4-[[(tert-butoxycarbonyl)amino]methyl] cyclohexanecarboxylic acid;trans-4 (tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid;trans-4- (tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid;TRANS-4-(T-BUTYLOXYCARBONYLAMINOMETHYL)-CYCLOHEXANOIC ACID;Trans-4-(t-butyloxycarbonylaminomethyl)cyclohexanecarboxylic acid;trans-4-(tert-butoxycarbonylamino-methyl)-cyclo-hexanecarboxylic acid;trans-4-(tert-butoxycarbonylamino-methyl)-cyclohexane-carboxylic acid;trans-4-(tert-butoxycarbonylamino-methyl)cyclohexanecarboxylic acid;trans-4-(tert.-butoxycarbonylaminomethyl) cyclohexanecarboxylic acid;trans-4-(tert.-butyloxycarbonylaminomethyl)cyclohexanecarboxylic acid;trans-4-{[(t-butoxycarbonyl) amino]methyl}cyclohexanecarboxylic acid;Trans-4-tert-butyloxycarbonylaminomethylcyclohexane carboxylic acid;trans-4-tert-Butyloxycarbonylaminomethylcyclohexanecarboxylic Acid;trans-N-(t-butoxycarbonyl)-4-(aminomethyl)cyclohexylcarboxylic acid;cis-4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid;cis-4-{[(tert-butoxycarbonyl)amino]methyl}-cyclohexanecarboxylic acid;N-(tert-butoxycarbonyl)-trans-4-(aminomethyl )-1-cyclohexanecarboxylic acid;trans-4-(tert.-butyloxycarbonylaminomethyl) cyclohexanecarboxylic acid;trans-4-{[(tert-butoxy)carbonylamino]methyl}cyclohexane carboxylic acid;trans-4-{[(tert-butoxy)carbonylamino]methyl}cyclohexanecarboxylic acid;trans-4-{[(tert-butoxycarbonyl)-amino]methyl}cyclohexanecarboxylic acid;(1s,4s)-4-({[(tert-butoxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid;cis-4-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]cyclohexanecarboxylic acid;Cyclohexanecarboxylic acid, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-;trans-4-[({[(2-methyl-2-propanyl)oxy]carbonyl}amino)methyl]cyclohexanecarboxylic acid;(1r,4r)-4-(((tert-butoxycarbonyl)amino)methyl)cyclohexane-1-carboxylic acid;Boc-(4-aminomethyl)cyclohexane carboxylic acid;trans-4-(tert-Butoxycarbonylaminomethyl)cyclohexanecarboxylic acid;TRANS-4-N-BOC-AMINOMETHYL-CYCLOHEXANECARBOXYLIC ACID

Chemical Property of 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid

Chemical Property:

• Melting Point: 133.0 to 137.0 °C
• Boiling Point: 410 °C at 760 mmHg
• PKA: 4.85±0.10(Predicted)
• Flash Point: 201.8 °C
• PSA: 75.63000
• Density: 1.096 g/cm³
• LogP: 2.79300
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 257.16270821
• Heavy Atom Count: 18
• Complexity: 301

Purity/Quality:

98% ^*data from raw suppliers

Boc-tranexamic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCC1CCC(CC1)C(=O)O

Technology Process of 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid

There total 6 articles about 4-(((tert-Butoxycarbonyl)amino)methyl)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) → trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid (27687-14-5)

Guidance literature:

With sodium hydrogencarbonate; In water; at 20 ℃; for 18h; Industrial scale;

Reference yield:

tert-butyldicarbonate (34619-03-9) + 4-aminomethyl-cyclohexanecarboxylic acid (1197-17-7,1197-18-8,701-54-2) → trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid (27687-14-5)

Guidance literature:

With sodium hydroxide; magnesium oxide; In 1,4-dioxane; CH₃ COOC₂ H₅; water;

Reference yield:

12N-hydrochloric acid + di-tert-butyl dicarbonate (24424-99-5) + trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) → trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid (27687-14-5)

Guidance literature:

With sodium chloride; triethylamine; In water (300 ml)-THF;

upstream raw materials:

di-tert-butyl dicarbonate

trans-4-aminomethyl-cyclohexyl-carboxylic acid

tert-butyldicarbonate

4-aminomethyl-cyclohexanecarboxylic acid

Downstream raw materials:

4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid 2,2-dimethyl-propionyloxymethyl ester

4-(tert-Butoxycarbonylamino-methyl)-cyclohexanecarboxylic acid isobutyryloxymethyl ester

(N,N-dimethylcarbamoyl)methylene bismethyl>cyclohexanecarboxylate>

C₃₀H₅₀N₂O₁₀

Refernces

• 1、 -. "ortho-Phthalaldehyde containing linkers and use for preparation of antibody-drug conjugate". Page/Page column 29; 32-35. . Retrieved 2020/06/10.
• 2、 Brennauer, Albert,Keller, Max,Freund, Matthias,Bernhardt, Günther,Buschauer, Armin. "Decomposition of 1-(ω-aminoalkanoyl)guanidines under alkaline conditions". . p. 6996 - 6999. Retrieved 2008/03/12.