3-(4-fluorophenyl)-1H-indazol-5-amine

Base Information

• Chemical Name: 3-(4-fluorophenyl)-1H-indazol-5-amine
• CAS No.: 395099-48-6
• Molecular Formula: C13H10FN3
• Molecular Weight: 227.241
• Mol file: 395099-48-6.mol

Synonyms:5-amino-3-(4-fluorophenyl)-1H-indazole;3-(4-Flurophenyl)-1H-Indazole-5-Ylamine;3-(4-fluoro-phenyl)-1H-indazol-5-ylamine;

Chemical Property of 3-(4-fluorophenyl)-1H-indazol-5-amine

Chemical Property:

• Boiling Point: 479.5±30.0 °C(Predicted)
• PKA: 13.85±0.40(Predicted)
• PSA: 54.70000
• Density: 1.361±0.06 g/cm3(Predicted)
• LogP: 3.53240
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Fluorophenyl)-1H-indazol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-fluorophenyl)-1H-indazol-5-amine

There total 3 articles about 3-(4-fluorophenyl)-1H-indazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-bromo-1H-indazol-5-amine (478837-59-1) + 4-fluoroboronic acid (1765-93-1) → 3-(4-fluoro-phenyl)-1H-indazol-5-ylamine (395099-48-6)

Guidance literature:

With potassium phosphate; palladium diacetate; ruphos; In 1,4-dioxane; water; at 140 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.tetlet.2015.04.024

Reference yield: 53.0%

1-{[3-(4-fluorophenyl)-5-nitro(1H-indazolyl)]methoxy}-2-methoxyethane → 3-(4-fluoro-phenyl)-1H-indazol-5-ylamine (395099-48-6)

Guidance literature:

In methanol; ethanol;

Reference yield:

C13H8FN3O2 (817200-27-4) → 3-(4-fluoro-phenyl)-1H-indazol-5-ylamine (395099-48-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; under 2585.81 Torr;

upstream raw materials:

C₁₃H₈FN₃O₂

3-bromo-1H-indazol-5-amine

4-fluoroboronic acid

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