2-Piperidinepropanol

Base Information

• Chemical Name: 2-Piperidinepropanol
• CAS No.: 24448-89-3
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.229
• Hs Code.: 2933399090
• NSC Number: 143038
• UNII: 54KDK4ZD39
• Nikkaji Number: J1.611.151A
• Mol file: 24448-89-3.mol

Synonyms:24448-89-3;2-PIPERIDINEPROPANOL;3-piperidin-2-ylpropan-1-ol;3-(Piperidin-2-yl)propan-1-ol;3-(2-piperidinyl)-1-propanol;3-(2-Piperidyl)-1-propanol;2-(3-Hydroxypropyl)piperidine;54KDK4ZD39;NSC-143038;NSC143038;piperidine 2-propanol;C(CCO)C1CCCCN1;UNII-54KDK4ZD39;SCHEMBL1843590;URCTXVMRFKFRMP-UHFFFAOYSA-N;2(r/s)-(3-hydroxypropyl)piperidine;MFCD06408773;AKOS005216302;AKOS016344216;NSC 143038;SB41336;BS-37583;3-Piperidin-2-ylpropan-1-ol, AldrichCPR;BB 0259755;CS-0231857;EN300-125656;F83137

Chemical Property of 2-Piperidinepropanol

Chemical Property:

• Vapor Pressure: 0.0091mmHg at 25°C
• Boiling Point: 235.5°C at 760 mmHg
• PKA: 15.18±0.10(Predicted)
• Flash Point: 90.2°C
• PSA: 32.26000
• Density: 0.929g/cm³
• LogP: 1.22980
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 85.3

Purity/Quality:

98% ^*data from raw suppliers

3-Piperidin-2-ylpropan-1-ol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)CCCO

Technology Process of 2-Piperidinepropanol

There total 21 articles about 2-Piperidinepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(pyridin-2-yl)-propanol (2859-68-9) → 2-(3-hydroxypropyl)piperidine (24448-89-3,33078-63-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; acetic acid; at 20 ℃; for 6h; under 760.051 Torr;

Reference yield: 95.0%

1-methoxycarbonyl-2-(3-hydroxypropyl)piperidine (112724-38-6) → 2-(3-hydroxypropyl)piperidine (24448-89-3,33078-63-6)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In ethylene glycol; for 1.5h; Heating;

DOI:10.1246/bcsj.60.215

Reference yield: 86.0%

(+/-)-2-[3-(benzyloxy)propyl]-N-tosylpiperidine (1359943-98-8) → 2-(3-hydroxypropyl)piperidine (24448-89-3,33078-63-6)

Guidance literature:

With naphthalene; sodium; In tetrahydrofuran; at -78 ℃; for 0.75h;

DOI:10.1055/s-0031-1289648

upstream raw materials:

piperidine

allyl alcohol

Dioxa-1,6 spiro<4.5>decane

3-(pyridin-2-yl)-propanol

Downstream raw materials:

phenylmethyl 2-{3-[6-amino-2-(butyloxy)-8-(methyloxy)-9H-purin-9-yl]propyl}-1-piperidinecarboxylate

phenylmethyl 2-(3-bromopropyl)-1-piperidinecarboxylate

phenylmethyl 2-(3-hydroxypropyl)-1-piperidinecarboxylate

indolizidine

Refernces

• 1、 Usuki, Toyonobu,Komatsu, Akira. "Preparation of monoalkylpiperidines via the mild hydrogenation of monoalkynylpyridines". supporting information. p. 2856 - 2858. Retrieved 2017/06/27.
• 2、 Reddy, Basi V. Subba,Chaya, Dudhmal N.,Yadav, Jhillu S.,Gree, Rene. "A concise and diastereoselective synthesis of piperidine and indolizidine alkaloids via aza-Prins cyclization". . p. 297 - 303. Retrieved 2012/03/26.