N-{[(4-Methoxyphenyl)methoxy]carbonyl}-L-tryptophan

Base Information

Chemical Name:N-{[(4-Methoxyphenyl)methoxy]carbonyl}-L-tryptophan
CAS No.:39545-09-0
Molecular Formula:C20H20N2O5
Molecular Weight:368.389
Hs Code.:
DSSTox Substance ID:DTXSID00552493

Synonyms:39545-09-0;N-{[(4-Methoxyphenyl)methoxy]carbonyl}-L-tryptophan;SCHEMBL11866933;DTXSID00552493

Suppliers and Price of N-{[(4-Methoxyphenyl)methoxy]carbonyl}-L-tryptophan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{[(4-Methoxyphenyl)methoxy]carbonyl}-L-tryptophan

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:368.13722174
Heavy Atom Count:27
Complexity:507

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)COC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)O
Isomeric SMILES:COC1=CC=C(C=C1)COC(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)O

Technology Process of N-{[(4-Methoxyphenyl)methoxy]carbonyl}-L-tryptophan

There total 1 articles about N-{[(4-Methoxyphenyl)methoxy]carbonyl}-L-tryptophan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: p-methoxy-carbobenzoxy azide H₃ CO-C₆ H₄ -CH₂ OCON₃

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 39545-09-0
p-methoxybenzyloxycarbonyl-Trp-OH

Guidance literature:: With hydrogenchloride; citric acid; In 1,4-dioxane; water; Petroleum ether;

Reference yield: 74.0%

: 39545-09-0
p-methoxybenzyloxycarbonyl-Trp-OH

: 100-51-6,185532-71-2
benzyl alcohol

: 92916-42-2
p-methoxybenzyloxycarbonyl-Trp-OBzl

Guidance literature:: With Amberlite XAD-8; immobilized papain (Carica papaya); In ethyl acetate; at 37 ℃; for 12h; pH=5.0;
DOI:10.1039/c39880000327

Reference yield:

: 39545-09-0
p-methoxybenzyloxycarbonyl-Trp-OH

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent

2: 98 percent / NaOH, cetyltrimetylammonium chloride / CH₂Cl₂ / 16 h

3: 87 percent / trifluoroacetic acid-anisole / 1 h

4: 100 percent / Phe, m-cresol, methanesulfonic acid, trifluoroacetic acid, thioanisole / 1 h / 0 °C / further acids, absence of thioanisole

With sodium hydroxide; methanesulfonic acid; methyl-phenyl-thioether; Phenylalanine; trifluoroacetic acid-anisole; cetyltrimethylammonium chloride; 3-methyl-phenol; trifluoroacetic acid; In dichloromethane;
DOI:10.1248/cpb.32.2660