p-methoxybenzyloxycarbonyl-Trp-OBzl

Base Information

• Chemical Name: p-methoxybenzyloxycarbonyl-Trp-OBzl
• CAS No.: 92916-42-2
• Molecular Formula: C₂₇H₂₆N₂O₅
• Molecular Weight: 458.514
• Mol file: 92916-42-2.mol

Synonyms:p-methoxybenzyloxycarbonyl-Trp-OBzl

Chemical Property of p-methoxybenzyloxycarbonyl-Trp-OBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-methoxybenzyloxycarbonyl-Trp-OBzl

There total 1 articles about p-methoxybenzyloxycarbonyl-Trp-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

p-methoxybenzyloxycarbonyl-Trp-OH (39545-09-0) + benzyl alcohol (100-51-6,185532-71-2) → p-methoxybenzyloxycarbonyl-Trp-OBzl (92916-42-2)

Guidance literature:

With Amberlite XAD-8; immobilized papain (Carica papaya); In ethyl acetate; at 37 ℃; for 12h; pH=5.0;

DOI:10.1039/c39880000327

Reference yield: 98.0%

2-mesitylenesulphonyl chloride (773-64-8) + p-methoxybenzyloxycarbonyl-Trp-OBzl (92916-42-2) → Z(OMe)-Trp(Mts)-OH (92916-43-3)

Guidance literature:

With sodium hydroxide; cetyltrimethylammonium chloride; In dichloromethane; for 16h;

DOI:10.1248/cpb.32.2660

Reference yield:

p-methoxybenzyloxycarbonyl-Trp-OBzl (92916-42-2) → L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / NaOH, cetyltrimetylammonium chloride / CH₂Cl₂ / 16 h

2: 87 percent / trifluoroacetic acid-anisole / 1 h

3: 100 percent / Phe, m-cresol, methanesulfonic acid, trifluoroacetic acid, thioanisole / 1 h / 0 °C / further acids, absence of thioanisole

With sodium hydroxide; methanesulfonic acid; methyl-phenyl-thioether; Phenylalanine; trifluoroacetic acid-anisole; cetyltrimethylammonium chloride; 3-methyl-phenol; trifluoroacetic acid; In dichloromethane;

DOI:10.1248/cpb.32.2660

upstream raw materials:

p-methoxybenzyloxycarbonyl-Trp-OH

benzyl alcohol

Downstream raw materials:

Z(OMe)-Trp(Mts)-OH

H-Trp(Mts)-OH

L-Tryptophan