2-Chloro-4-methylbenzyl alcohol

Base Information

• Chemical Name: 2-Chloro-4-methylbenzyl alcohol
• CAS No.: 39652-31-8
• Molecular Formula: C8H9ClO
• Molecular Weight: 156.612
• Mol file: 39652-31-8.mol

Synonyms:(2-Chloro-4-methyl-phenyl)-methanol;2-Chlor-4-methyl-benzylalkohol;2-chloro-4-methylbenzyl alcohol;

Chemical Property of 2-Chloro-4-methylbenzyl alcohol

Chemical Property:

• PSA: 20.23000
• LogP: 2.14070

Purity/Quality:

97% ^*data from raw suppliers

(2-chloro-4-methylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-4-methylbenzyl alcohol

There total 4 articles about 2-Chloro-4-methylbenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-methyl-benzaldehyde (50817-80-6) → (2-chloro-4-methylphenyl)methanol (39652-31-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃; Inert atmosphere; Schlenk technique; Glovebox;

Reference yield:

methyl 2-chloro-4-methylbenzoate (195318-63-9) → (2-chloro-4-methylphenyl)methanol (39652-31-8)

Guidance literature:

methyl 2-chloro-4-methylbenzoate; With diisobutylaluminium hydride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With rochelle salt; In dichloromethane; for 1h;

Reference yield:

1-bromo-2-chloro-4-methylbenzene (6627-51-6) → (2-chloro-4-methylphenyl)methanol (39652-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -88 °C / Inert atmosphere; Schlenk technique; Glovebox

1.2: 20 °C / Inert atmosphere; Schlenk technique; Glovebox

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere; Schlenk technique; Glovebox

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; methanol; hexane;

upstream raw materials:

methyl 2-chloro-4-methylbenzoate

2-chloro-4-methyl-benzaldehyde

1-bromo-2-chloro-4-methylbenzene

Downstream raw materials:

2-chloro-4-methylbenzyl methanesulfonate

(2-chloro-4-methylphenyl)methyl acetate

3-(2-chloro-4-methylphenyl)-2-methylpropanoyl chloride

C₁₁H₁₃ClO₂